水泥生产工人肺功能下降：一项荟萃分析。

Decline in lung function among cement production workers: a meta-analysis.

机构信息

出版信息

Rev Environ Health. 2017 Dec 20;32(4):333-341. doi: 10.1515/reveh-2017-0017.

DOI:10.1515/reveh-2017-0017

Abstract

BACKGROUND

Several studies with different results have been performed regarding cement dust exposure and its pathogenic outcomes during the previous years. This study aims to combine these results to obtain a reliable estimate of the effect of exposure to cement dust.

METHODS

PubMed and other data banks were searched to identify required electronic articles. The search was extended interviewing with relevant experts and research centers. Point and pooled estimates of outcome with 95% confidence intervals were estimated.

RESULTS

Participants were 5371 exposed and 2650 unexposed persons. Total mean differences (95% confidence intervals) were estimated as of -0.48 (-0.71 to -0.25) L for forced vital capacity (FVC), -0.7 (-0.92 to -0.47) L for forced expiratory volume in the first second (FEV1), -0.43 (-0.68 to -0.19) L for FEV1/FVC%, -0.73 (-1.15 to -0.30) L/min for PEFR and -0.36 (-0.51 to -0.21) L/s for FEF25-75.

CONCLUSION

Our meta-analysis showed that cement dust has significant impact on lung function and reduces the indicators of FVC, FEV1, FEV1/FVC, PEFR and FEF25-75.

摘要

背景

近年来，已有多项研究对水泥尘暴露及其致病结果进行了研究，结果不尽相同。本研究旨在综合这些结果，以获得对水泥尘暴露影响的可靠估计。

方法

在 PubMed 和其他数据库中搜索所需的电子文章。通过采访相关专家和研究中心，对搜索进行了扩展。采用点估计和汇总估计，计算了 95%置信区间的结局指标。

结果

研究对象包括 5371 名暴露组和 2650 名非暴露组。总平均差异（95%置信区间）估计为：用力肺活量（FVC）减少 0.48（-0.71 至-0.25）L，第一秒用力呼气量（FEV1）减少 0.7（-0.92 至-0.47）L，FEV1/FVC%减少 0.43（-0.68 至-0.19）L，呼气峰流速（PEFR）减少 0.73（-1.15 至-0.30）L/min，25%至 75%肺活量时的平均呼气流速（FEF25-75）减少 0.36（-0.51 至-0.21）L/s。