Korfali E, Doygun M, Ulus I H, Rakunt C, Aksoy K
Department of Neurosurgery, Uludag University School of Medicine, Bursa, Turkey.
Neurosurgery. 1988 Jun;22(6 Pt 1):994-8. doi: 10.1227/00006123-198806010-00003.
The effects of neuronotrophic factors (NFs) on adult adrenal medulla grafts transplanted into the rat caudate nucleus after the destruction of the nigrostriatal dopaminergic pathways were investigated. Two months after implantation, all of the adrenal medulla grafts treated with NFs, but only 45% of the untreated grafts, had survived. The levels of tyrosine hydroxylase activity in the caudate nucleus however, were not significantly different between the sham-operated control and either NF-treated or untreated grafted groups. These results indicate that treatment with NFs significantly enhances the survival rate of the grafts.
研究了神经营养因子（NFs）对黑质纹状体多巴胺能通路破坏后移植到大鼠尾状核的成年肾上腺髓质移植物的影响。植入后两个月，所有接受NFs治疗的肾上腺髓质移植物都存活了下来，但未治疗的移植物只有45%存活。然而，假手术对照组与接受NFs治疗或未治疗的移植组之间，尾状核中酪氨酸羟化酶活性水平没有显著差异。这些结果表明，NFs治疗可显著提高移植物的存活率。
