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严重发作性腰痛病史是否提示椎间盘源性病因?

Is a History of Severe Episodic Low Back Pain an Indicator of a Discogenic Etiology?

机构信息

APM Spine and Sports Physicians, Virginia Beach, Virginia.

Department of Orthopaedic Surgery, Stanford School of Medicine, Redwood City, California, USA.

出版信息

Pain Med. 2018 Jul 1;19(7):1334-1339. doi: 10.1093/pm/pnx147.

Abstract

OBJECTIVE

To determine if a history of severe episodic low back pain (LBP) correlates with positive discography.

METHODS

A retrospective chart review identified patients undergoing discography from January 2012 through February 2016. The review determined if the patient's LBP began or continued with severe disabling episodes (lasting a minimum of two days). A gradual onset or initiating event with continuous symptoms was considered a nonepisodic history. Patients were excluded for unclear record, workers' compensation, litigation, prior lumbar surgery, radiologic instability, or indeterminate discography.

RESULTS

Seventy-eight patients underwent discography. Thirty-nine patients were included, 31 of which had positive discograms. Eight had negative discograms. Nineteen patients had a history of episodic LBP, and 20 had no history of episodic LBP. Of those 19 with a history of episodic LBP, 18 had positive discography and one had negative discography. Of those with no history of episodic LBP, 13 had positive discography and seven had negative discography. Using the historical finding of severe episodic LBP as a test for discogenic source of LBP, the sensitivity is 58% (95% confidence interval [CI] = 41-75%) and the specificity is 88% (95% CI = 65-100%). The likelihood ratio is 4.7 (95% CI = 0.72-30). The positive predictive value (PPV) is 95% (95% CI = 72-100%). The PPV is based upon a prevalence of 79% (discogram positive) in our sample of patients considering fusion surgery. The diagnostic confidence odds are 18.2, with a diagnostic confidence of 95%.

CONCLUSIONS

A positive history of severe episodic LBP may be a strong indicator for a discogenic etiology.

摘要

目的

确定严重阵发性腰痛(LBP)病史是否与椎间盘造影阳性相关。

方法

回顾性图表审查确定了 2012 年 1 月至 2016 年 2 月期间接受椎间盘造影的患者。审查确定患者的 LBP 是否开始或持续出现严重致残性发作(持续至少两天)。逐渐发作或伴有持续症状的起始事件被认为是无阵发性病史。对于记录不明确、工人赔偿、诉讼、先前的腰椎手术、放射不稳定或不确定的椎间盘造影的患者,将其排除在外。

结果

78 例患者接受了椎间盘造影。39 例患者被纳入研究,其中 31 例椎间盘造影阳性。8 例椎间盘造影阴性。19 例患者有阵发性 LBP 病史,20 例患者无阵发性 LBP 病史。在 19 例有阵发性 LBP 病史的患者中,18 例椎间盘造影阳性,1 例椎间盘造影阴性。在无阵发性 LBP 病史的患者中,13 例椎间盘造影阳性,7 例椎间盘造影阴性。将严重阵发性 LBP 的病史发现作为 LBP 椎间盘源性的测试,其敏感性为 58%(95%置信区间 [CI] = 41-75%),特异性为 88%(95% CI = 65-100%)。比值比为 4.7(95% CI = 0.72-30)。阳性预测值(PPV)为 95%(95% CI = 72-100%)。PPV 是基于我们的融合手术患者样本中 79%(椎间盘造影阳性)的患病率。诊断置信度比值为 18.2,诊断置信度为 95%。

结论

严重阵发性 LBP 的阳性病史可能是椎间盘源性病因的有力指标。

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