Taghadomi Masoumi Zahra, Eshraghian Mohammad Reza, Hedayati Mahdi, Pishva Hamideh
a Department of cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.
b Department of Epidemiology and Biostatistics, School of Public Health , Tehran University of Medical Sciences , Tehran , Iran.
Gynecol Endocrinol. 2018 Feb;34(2):166-170. doi: 10.1080/09513590.2017.1379492. Epub 2017 Oct 10.
Obesity is recognized as the most prevalent metabolic disease worldwide. Decreases in energy expenditure may increase risk of obesity. One of the key regulators of energy balance is uncoupling protein2 (UCP2), a transporter protein presents in mitochondrial inner membrane. Moreover, adiponectin is the most abundant adipocytokine, it may play a role in energy metabolism and gene expression of UCP2. The aim of this study was to investigate potential associations between the level of uncoupling protein 2 and adiponectin and their relationship with REE (Resting Energy Expenditure) in obese women with normal and low resting energy expenditure. A total of 49 subjects (women, 25-50 years old), were included in current study, 16 subjects with BMI > 30 and low resting energy expenditure, 17 subjects with BMI > 30 and normal resting energy expenditure and 16 non-obese subjects as a control group. Anthropometric, body composition parameters and resting energy expenditure were measured. Plasma adiponectin, UCP2 protein and total protein in PBMC were determined. Measured resting energy expenditure in obese subjects with low REE was significantly lower than other groups. Plasma adiponectin in the obese subjects with low REE was significantly lower compared to normal weight group. There was a significant relationship between 'UCP2 protein/Total protein' ratio and plasma adiponectin in obese group with low REE and in three groups when we pooled. There was a significant association between REE and plasma adiponectin in three groups when we pooled. There was a significant association between plasma adiponectin and REE. Moreover, there was a significant relationship between UCP2 and REE.
肥胖被认为是全球最普遍的代谢性疾病。能量消耗减少可能会增加肥胖风险。能量平衡的关键调节因子之一是解偶联蛋白2（UCP2），它是一种存在于线粒体内膜的转运蛋白。此外，脂联素是最丰富的脂肪细胞因子，它可能在能量代谢和UCP2的基因表达中发挥作用。本研究的目的是调查正常和低静息能量消耗的肥胖女性中解偶联蛋白2和脂联素水平之间的潜在关联及其与静息能量消耗（REE）的关系。本研究共纳入49名受试者（25至50岁女性），16名BMI>30且静息能量消耗低的受试者，17名BMI>30且静息能量消耗正常的受试者，以及16名非肥胖受试者作为对照组。测量了人体测量学、身体成分参数和静息能量消耗。测定了血浆脂联素、UCP2蛋白和外周血单核细胞中的总蛋白。低REE肥胖受试者的实测静息能量消耗显著低于其他组。与正常体重组相比，低REE肥胖受试者的血浆脂联素显著降低。在低REE肥胖组以及合并后的三组中，“UCP2蛋白/总蛋白”比值与血浆脂联素之间存在显著关系。合并后的三组中，REE与血浆脂联素之间存在显著关联。血浆脂联素与REE之间存在显著关联。此外，UCP2与REE之间存在显著关系。
