Ahmadi Somaye, Pishva Hamideh, Eshraghian Mohammad R, Hedayati Mehdi
Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Endocr Metab Immune Disord Drug Targets. 2020;20(2):234-241. doi: 10.2174/1871530319666190723154147.
The aim of this study was to investigate the association of Sex Hormone Binding Globulin (SHBG) with leptin, Triidothyronine (T3), and Uncoupling Protein 2 (UCP2) in obese women with low and normal Resting Energy Expenditure (REE) and to determine the role of these factors in the regulation of REE in obese women.
A total 49 subjects (25-50 years old) were selected. Anthropometric and body composition parameters and resting energy expenditure were measured. Fasting circulating leptin, T3, SHBG and UCP2 levels were measured. Subjects were divided into three groups: Group І (BMI>30 and low resting energy expenditure, 16 subjects), group II (BMI>30 and normal resting energy expenditure, 17 subjects), and group ІІІ (control group, 16 non-obese subjects).
It was found that obese subjects who had higher SHBG and leptin levels were at risk for high levels of UCP2. A significant association was found between T3 and REE. Obese subjects with higher concentrations of UCP2 and SHBG had decreased resting energy expenditure. A significant association was observed between SHBG and leptin in group І (r=0.90, p<0.0001) and group ІІ (r=0.83, p<0.0001). Moreover, a significant association was found between T3 and SHBG in group І (r=-0.69, P=0.003).
Changes of the UCP2, leptin, and thyroid hormone (T3) levels may be related to SHBG levels. Thus, lower leptin and T3 levels may decrease SHBG in obese women. Therefore, lower SHBG, leptin, T3 and UCP2 levels may decrease the REE level in obese women.
本研究旨在调查性激素结合球蛋白（SHBG）与瘦素、三碘甲状腺原氨酸（T3）和解偶联蛋白2（UCP2）在静息能量消耗（REE）低和正常的肥胖女性中的关联，并确定这些因素在肥胖女性REE调节中的作用。
共选取49名受试者（25 - 50岁）。测量人体测量学和身体成分参数以及静息能量消耗。测量空腹循环瘦素、T3、SHBG和UCP2水平。受试者分为三组：第一组（BMI>30且静息能量消耗低，16名受试者），第二组（BMI>30且静息能量消耗正常，17名受试者），第三组（对照组，16名非肥胖受试者）。
发现SHBG和瘦素水平较高的肥胖受试者有UCP2水平升高的风险。T3与REE之间存在显著关联。UCP2和SHBG浓度较高的肥胖受试者静息能量消耗降低。在第一组（r = 0.90，p<0.0001）和第二组（r = 0.83，p<0.0001）中，SHBG与瘦素之间存在显著关联。此外，在第一组中T3与SHBG之间存在显著关联（r = -0.69，P = 0.003）。
UCP2、瘦素和甲状腺激素（T3）水平的变化可能与SHBG水平有关。因此，较低的瘦素和T3水平可能会降低肥胖女性的SHBG。所以，较低的SHBG、瘦素、T3和UCP2水平可能会降低肥胖女性的REE水平。
