Bedel Hatice Asli, Kencebay Manas Ceren, Özbey Gül, Usta Coşkun
a Faculty of Medicine, Department of Pharmacology , Akdeniz University , Antalya , Turkey.
b Faculty of Medicine, Department of Biophysics , Akdeniz University , Antalya , Turkey.
Nat Prod Res. 2018 Dec;32(24):2932-2935. doi: 10.1080/14786419.2017.1385021. Epub 2017 Oct 11.
The aim of present study was to evaluate the antidepressant-like activity of ellagic acid (EA) in mice-forced swim test (FST) and tail suspension test (TST) and the possible role of brain-derived neurotrophic factor (BDNF) in EA's antidepressant-like effect. We found that EA and sertraline did not affect the spontaneous locomotor activity of mice. EA produced statistically significant decrease in immobility time as compared to vehicle group in TST. EA at 1 and 5 mg/kg doses did not produce any significant effect in immobility time as compared to vehicle group in FST. But EA produced significantly reduced immobility time at 2.5 mg/kg dose. EA treatment increased hippocampal BDNF level. This study demonstrates that EA is able to produce antidepressant-like effect in both TST and FST in mice. Moreover, the antidepressant-like effects of EA seems to be mediated by increased BDNF level in mice hippocampus.
本研究的目的是在小鼠强迫游泳试验（FST）和悬尾试验（TST）中评估鞣花酸（EA）的抗抑郁样活性，以及脑源性神经营养因子（BDNF）在EA抗抑郁样作用中可能发挥的作用。我们发现EA和舍曲林不影响小鼠的自发运动活性。与溶媒组相比，EA在TST中使不动时间产生了具有统计学意义的减少。与溶媒组相比，1和5mg/kg剂量的EA在FST中对不动时间未产生任何显著影响。但2.5mg/kg剂量的EA使不动时间显著减少。EA处理提高了海马体BDNF水平。本研究表明，EA能够在小鼠的TST和FST中产生抗抑郁样作用。此外，EA的抗抑郁样作用似乎是由小鼠海马体中BDNF水平升高介导的。
