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比较氟西汀、艾司西酞普兰和舍曲林在临床前和临床研究中对 BDNF 水平和抑郁的影响：系统评价。

Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review.

机构信息

Department of Psychology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Department of Power Electronic, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran.

出版信息

Eur J Clin Pharmacol. 2024 Jul;80(7):983-1016. doi: 10.1007/s00228-024-03680-y. Epub 2024 Apr 1.

DOI:10.1007/s00228-024-03680-y
PMID:38558317
Abstract

Brain-derived neurotrophic factor (BDNF) dysfunction is one of the most important mechanisms underlying depression. It seems that selective serotonin reuptake inhibitors (SSRIs) improve depression via affecting BDNF level. In this systematic review, for the first time, we aimed to review the effect of three SSRIs including fluoxetine, escitalopram, and sertraline, on both depression and BDNF level in preclinical and clinical studies. PubMed electronic database was searched, and 193 articles were included in this study. After reviewing all manuscripts, only one important difference was found: subjects. We found that SSRIs induce different effects in animals vs. humans. Preclinical studies showed many controversial effects, while human studies showed only two effects: improvement of depression, with or without the improvement of BDNF. However, most studies used chronic SSRIs treatment, while acute SSRIs were not effectively used and evaluated. In conclusion, it seems that SSRIs are reliable antidepressants, and the improvement effect of SSRIs on depression is not dependent to BDNF level (at least in human studies).

摘要

脑源性神经营养因子（BDNF）功能障碍是抑郁症的最重要机制之一。似乎选择性 5-羟色胺再摄取抑制剂（SSRIs）通过影响 BDNF 水平来改善抑郁症。在本次系统评价中，我们首次旨在综述包括氟西汀、艾司西酞普兰和舍曲林在内的三种 SSRIs 在临床前和临床研究中对抑郁和 BDNF 水平的影响。检索了 PubMed 电子数据库，共有 193 篇文章纳入本研究。在回顾了所有的文献后，我们只发现了一个重要的区别：研究对象。我们发现，SSRIs 在动物和人类中会产生不同的作用。临床前研究显示出许多有争议的作用，而人体研究仅显示出两种作用：改善抑郁，伴有或不伴有 BDNF 的改善。然而，大多数研究使用慢性 SSRIs 治疗，而没有有效地使用和评估急性 SSRIs。总之，SSRIs 似乎是可靠的抗抑郁药，SSRIs 对抑郁的改善作用不依赖于 BDNF 水平（至少在人体研究中）。

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[5]
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[6]
Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review.

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[7]
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[8]
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本文引用的文献

[1]
Red Raspberry Extract Decreases Depression-Like Behavior in Rats by Modulating Neuroinflammation and Oxidative Stress.

Biomed Res Int. 2022

[2]
Total Saikosaponins Attenuates Depression-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats by Regulating the PI3K/AKT/NF-B Signaling Axis.

Evid Based Complement Alternat Med. 2022-6-18

[3]
Traditional herbal formula Jiao-tai-wan improves chronic restrain stress-induced depression-like behaviors in mice.

Biomed Pharmacother. 2022-9

[4]
Rapid-Onset Antidepressant-Like Effect of in Social Hierarchy Stress Model of Depression.

Evid Based Complement Alternat Med. 2022-5-29

[5]
Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms.

Transl Psychiatry. 2022-5-19

[6]
extract in the treatment of depression and serum Brain-Derived Neurotrophic Factor (BDNF) levels.

J Res Med Sci. 2022-4-15

[7]
Creatine and Alpha-Lipoic Acid Antidepressant-Like Effect Following Cyclosporine A Administration.

Turk J Pharm Sci. 2022-4-29

[8]
Crocin ameliorates depressive-like behaviors induced by chronic restraint stress via the NAMPT-NAD-SIRT1 pathway in mice.

Neurochem Int. 2022-7

[9]
Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice.

Pharmacology. 2022

[10]
Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels.

Behav Brain Res. 2022-5-3

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