Samad Noreen, Ishaq Sara, Bano Shehr, Manzoor Natasha
Department of Biochemistry, Bahauddin Zakariya University, Multan-60800.
J Coll Physicians Surg Pak. 2017 Sep;27(9):566-571.
This study is systematic review of the research, focused on all possible pathways involved in calcium (Ca2+) regulation in order to utilize them in the control and remediation of Alzheimer's disease (AD), because Ca2+ plays important role in pathogenesis of AD. Electronic databases, Science Direct and PubMed/Medline, for relevant publications between 2000April 2017, were searched. Ca2+ ions are very important in cell signaling in body, specially the neuronal signaling. Many pathways are involved in normal neuronal Ca2+ signaling. AD is one of the most commonly known neurodegenerative disorders, causing dementia and some other neuropathological signs in mostly elderly people reaching a rate of 44 million until now. Depending upon certain possibilities, many hypothesis were proposed related to AD; out of which, one is Ca2+ hypothesis. According to this hypothesis, disturbance in Ca2+ signaling pathway due to certain reasons, such as accumulation of beta-amyloid proteins, ER stress, cytochrome c activation etc., causes AD. Due to less clinical research, only few FDAapproved pharmaceuticals are available for treatment of AD. Reviewed studies suggest that Ca2+ channel blocker and initiator may play an important role in cure of AD.
本研究是一项系统性研究综述，聚焦于钙（Ca2+）调节所涉及的所有可能途径，以便将其用于阿尔茨海默病（AD）的控制和治疗，因为Ca2+在AD的发病机制中起着重要作用。检索了电子数据库Science Direct和PubMed/Medline，以查找2000年至2017年4月期间的相关出版物。Ca2+离子在人体细胞信号传导中非常重要，特别是在神经元信号传导中。正常的神经元Ca2+信号传导涉及许多途径。AD是最常见的神经退行性疾病之一，主要在老年人中导致痴呆和其他一些神经病理学症状，目前患者人数已达4400万。基于某些可能性，人们提出了许多与AD相关的假说；其中之一是Ca2+假说。根据这一假说，由于某些原因，如β-淀粉样蛋白积累、内质网应激、细胞色素c激活等导致Ca2+信号通路紊乱，从而引发AD。由于临床研究较少，目前仅有少数经美国食品药品监督管理局（FDA）批准的药物可用于治疗AD。综述研究表明，Ca2+通道阻滞剂和启动剂可能在AD的治疗中发挥重要作用。
