Wang Xin Li, Jiang Gui Jin, Zhang Xue Zhu, Chu Liang Ming, Cao Ying
Department of Pathology, Guizhou People's Hospital, China.
Department of Pathology, Jinhu County People's Hospital, Jiangsu Province, China.
J Coll Physicians Surg Pak. 2017 Sep;27(9):582-583.
Pulmonary papillary adenoma is a rare tumor. Two cases without any clinical symptoms were enrolled in our hospital. Both cases were incidentally detected in pulmonary area by imaging. Pathological examination revealed well-circumscribed nodules consisting of papillary growth of cuboidal to low columnar epithelial cells lining the surface of the fibrovascular stroma. Immunohistochemistry (IHC) staining showed that the lining cells were diffusely positive for TTF-1, CK, p63, CK7, and Napsin A. The Ki-67 proliferation index was approximately 2%. The morphological features and the IHC profile of the tumor were in agreement with that of pulmonary papillary adenoma. Both patients are doing well without recurrence or metastasis of the tumor.
肺乳头状腺瘤是一种罕见肿瘤。我院收治了2例无任何临床症状的病例。这2例均通过影像学检查在肺部偶然发现。病理检查显示结节边界清晰，由立方状至低柱状上皮细胞呈乳头状生长排列于纤维血管间质表面构成。免疫组化（IHC）染色显示，衬里细胞TTF-1、CK、p63、CK7和Napsin A弥漫性阳性。Ki-67增殖指数约为2%。肿瘤的形态学特征和免疫组化表现与肺乳头状腺瘤相符。两名患者情况良好，肿瘤无复发或转移。
