Gorostiaga Iñigo, Martinez-Aracil Adriano, Catón Blanca, Perez-Rodriguez Alvaro
Osakidetza Basque Health Service, Araba University Hospital, Pathology Service, Alava, Vitoria-Gasteiz, Spain.
Osakidetza Basque Health Service, Araba University Hospital, Pathology Service, Alava, Vitoria-Gasteiz, Spain.
Rev Esp Patol. 2021 Jul-Sep;54(3):206-210. doi: 10.1016/j.patol.2020.07.002. Epub 2020 Sep 1.
Pulmonary papillary adenoma (PA) is an unusual tumor with only 32 reported cases to date. We present a case of a 69-year-old man, a smoker from the age of 12, with a central mass in the pulmonary left lower lobe identified in a PET-CT scan. Microscopical analysis of the Fine Needle Aspiration (FNA) samples showed fragments of a tumor comprised of abundant papillary structures lined by a monolayer of cytologically bland columnar to cuboidal epithelial cells. The immunohistochemical stains were positive for CK7, TTF-1 and EMA in the epithelial cells, and negative for MYC. Based on the imaging tests, histological features and immunohistochemical profile, the tumor was diagnosed as pulmonary PA. The cytologic and histologic features of this rare entity are described in detail and the value of FNA as an essential presurgical diagnostic procedure is emphasized.
肺乳头状腺瘤（PA）是一种罕见的肿瘤，迄今为止仅有32例报道。我们报告一例69岁男性病例，该患者自12岁起吸烟，在PET-CT扫描中发现左肺下叶有一中央肿块。细针穿刺抽吸（FNA）样本的显微镜分析显示肿瘤碎片由丰富的乳头状结构组成，内衬单层细胞学上温和的柱状至立方上皮细胞。上皮细胞的免疫组化染色显示CK7、TTF-1和EMA呈阳性，MYC呈阴性。根据影像学检查、组织学特征和免疫组化特征，该肿瘤被诊断为肺PA。详细描述了这种罕见实体的细胞学和组织学特征，并强调了FNA作为术前必要诊断程序的价值。
