Hokkaido University, Center for Environmental and Health Sciences, Sapporo, Japan.
Sapporo Medical University, School of Health Science, Sapporo, Japan.
Sci Total Environ. 2018 Mar 15;618:1423-1430. doi: 10.1016/j.scitotenv.2017.09.267. Epub 2017 Oct 7.
Prenatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs) or polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dioxin-like compounds [DLCs]) through environmental chemicals may affect the neurodevelopment of children. In our previous study, an inverse association was observed between prenatal DLCs and neurodevelopment of infants aged 6months in both sexes. However, studies are yet to determine how long these adverse effects last.
To examine whether the effects of DLCs on cognitive development remains at 42months.
In this prospective cohort study conducted in Sapporo, Japan, pregnant mothers' blood was analyzed for the congener level of DLCs. The Kaufman Assessment of Battery for Children (K-ABC) was used to test their children's cognitive development at 42months. A total of 141 mother-child pairs were included in the final analysis. The multiple linear regression analysis was used to examine the association between the K-ABC scores and DLC levels in the maternal blood.
Seven isomers (1,2,3,6,7,8-HxCDD, 2,3,4,7,8-PeCDF, 33'44'55'-HxCB(#169), 2344'5- PenCB(#114), 233'44'5-HexCB(#156), 233'44'5'-HexCB(#157), 23'44'55'-HexCB(#167), total PCDF, and TEQ-PCDD, PCDF, PCDD/DFs levels were positively associated with the achievement score (AS) of K-ABC. However, total non-ortho PCBs were negatively associated with the Mental Processing Composite Score (MPCS) of K-ABC in males. In females, increased TEQ-dl PCB and TEQ-PCDD/F/dl-PCB were also associated with increasing AS score.
This study suggests that the negative effects of prenatal DLC exposure on children's cognitive development at 6months were not observed in children aged 42months. Regarding the sex-specific effects, AS and DLCs were positively correlated in females, whereas those of MPCS and DLCs were significantly negative in males.
通过环境化学物质，产前暴露于多氯二苯并对二恶英（PCDDs）或多氯二苯并呋喃（PCDFs）和类似二恶英的多氯联苯（类似二恶英的化合物[DLCs]）可能会影响儿童的神经发育。在我们之前的研究中，在 6 个月大的男女婴儿中，发现产前 DLCs 与婴儿的神经发育呈负相关。然而，目前的研究尚未确定这些不良影响会持续多久。
检查 DLCs 对认知发展的影响是否在 42 个月时仍然存在。
在日本札幌进行的这项前瞻性队列研究中，分析了孕妇血液中 DLC 同系物的水平。使用 Kaufman 儿童评估量表（K-ABC）在 42 个月时测试其子女的认知发育情况。共有 141 对母婴对进入最终分析。采用多元线性回归分析，检查母体血液中 DLC 水平与 K-ABC 评分之间的关联。
七种同系物（1,2,3,6,7,8-HxCDD、2,3,4,7,8-PeCDF、33'44'55'-HxCB（#169）、2344'5-PenCB（#114）、233'44'5-HexCB（#156）、233'44'5'-HexCB（#157）、23'44'55'-HexCB（#167）、总 PCDF 和 TEQ-PCDD、PCDF、PCDD/DFs 水平与 K-ABC 的成就得分（AS）呈正相关。然而，总非邻苯二甲酸二丁酯在男性中与 K-ABC 的心理加工综合得分（MPCS）呈负相关。在女性中，TEQ-dl PCB 和 TEQ-PCDD/F/dl-PCB 的增加也与 AS 得分的增加有关。
本研究表明，产前 DLC 暴露对 6 个月大儿童认知发育的负面影响在 42 个月大的儿童中并未观察到。关于性别特异性影响，AS 和 DLCs 在女性中呈正相关，而在男性中，MPCS 和 DLCs 的相关性显著为负。
