Nakajima Sonomi, Saijo Yasuaki, Miyashita Chihiro, Ikeno Tamiko, Sasaki Seiko, Kajiwara Junboku, Kishi Reiko
School of Health Sciences, Sapporo Medical University, Minami 1, Nishi 17, Chuo-ku, Sapporo 060-8556, Japan.
Department of Health Sciences, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan.
Environ Res. 2017 Nov;159:222-231. doi: 10.1016/j.envres.2017.08.006. Epub 2017 Aug 10.
Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known.
We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects.
The levels of all and each individual DLC isomers were estimated in maternal peripheral blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development-2nd Edition for 6-month-old infants (n = 190) and 18-month-old children (n = 121).
In male children, levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables. However, at 18 months of age, these associations were absent. In female children, the level of only one DLC isomer was significantly negatively associated with PDI at 6 months of age. However, in contrast to the male children, the levels of six DLC isomers in 18-month-old female children were significantly positively associated with the Mental Developmental Index.
These findings indicate that adverse neurodevelopmental effects of prenatal background-level exposure to DLCs may be stronger in male children.
关于二噁英类多氯联苯（PCBs）和多氯二苯并对二噁英（PCDDs）/多氯二苯并呋喃（PCDFs）（二噁英类化合物 [DLCs]）对儿童神经发育的影响，尚无一致的报告。此外，个体DLC异构体背景水平暴露的影响尚不清楚。
我们开展了札幌队列研究，以评估产前暴露于每种DLC异构体对6个月和18个月大儿童神经发育的影响，并评估这些影响中的性别差异。
估计母体外周血中所有及每种DLC异构体的水平。使用贝利婴幼儿发育量表第二版对6个月大的婴儿（n = 190）和18个月大的儿童（n = 121）进行神经发育评估。
在男性儿童中，调整潜在混杂变量后，10种DLC异构体的水平与6个月大时的心理运动发育指数（PDI）显著负相关。然而，在18个月大时，这些关联不存在。在女性儿童中，只有一种DLC异构体的水平与6个月大时的PDI显著负相关。然而，与男性儿童不同的是，18个月大的女性儿童中6种DLC异构体的水平与智力发育指数显著正相关。
这些发现表明，产前背景水平暴露于DLCs对神经发育的不良影响在男性儿童中可能更强。
