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早产儿体重不足 2 公斤时动脉导管未闭的封堵:外科手术与经导管治疗。

Patent Ductus Arteriosus closure in preterms less than 2kg: Surgery versus transcatheter.

机构信息

Erciyes University School of Medicine, Division of Pediatric Cardiology, Kayseri, Turkiye,.

Erciyes University School of Medicine, Division of Cardiovascular Surgery, Kayseri, Turkiye.

出版信息

Int J Cardiol. 2018 Jan 1;250:110-115. doi: 10.1016/j.ijcard.2017.10.020. Epub 2017 Oct 6.

Abstract

BACKGROUND

As new devices come into the market, percutaneous techniques improve and interventionalists become more experienced; percutaneous closure gets more common in preterms. In this study we aimed to compare efficacy and safety of Patent Ductus Arteriosus closure surgically versus transcatheter method in preterms <2kg. Best of our knowledge this study is the first one that compares outcomes of surgery and percutaneous Patent Ductus Arteriosus closure in preterms.

METHODS & RESULTS: Between the dates July 1997 to October 2014 in our center Patent Ductus Arteriosus of 26 patients <2kg were closed percutaneously (Group A) and 31 less than 2kg operated (Group B). Weight of patients in percutaneous Patent Ductus Arteriosus closure group was significantly more than the surgery group. Mean gestational age of the patients in Group A was 30±1.8weeks, in group B was 28.6±3.5weeks. In group A; all cases were closed successfully except 4 cases: device embolization in 2, cardiac tamponade and iatrogenic aortic coarctation were seen. Pneumomediastinum and chylothorax were the major complications of the surgery group. There was no statistically significance between complication and success rates between two groups.

CONCLUSION

Percutaneous Patent Ductus Arteriosus closure is the candidate for taking the place of surgery in preterms. However, it is not applied routinely; can only be done in fully equipped large centers by experienced interventionalists.

摘要

背景

随着新设备进入市场,介入技术不断改进,介入专家经验更加丰富,早产儿中经皮介入关闭动脉导管未闭(PDA)的比例越来越高。本研究旨在比较<2kg 的早产儿经皮与外科手术关闭动脉导管未闭的疗效和安全性。据我们所知,这是首次比较手术与经皮 PDA 关闭术治疗早产儿的研究。

方法和结果

1997 年 7 月至 2014 年 10 月,我们中心对 26 例<2kg 的患儿行经皮 PDA 关闭术(A 组),对 31 例<2kg 的患儿行外科手术(B 组)。A 组患儿体重明显高于 B 组。A 组患儿的平均胎龄为 30±1.8 周,B 组为 28.6±3.5 周。A 组中除 4 例(2 例器械栓塞,1 例心脏压塞,1 例医源性主动脉缩窄)外,所有病例均成功关闭。外科组的主要并发症为气胸和乳糜胸。两组间并发症和成功率无统计学差异。

结论

经皮 PDA 关闭术有望替代手术治疗早产儿,但目前尚未常规应用,只能由经验丰富的介入专家在设备齐全的大型中心进行。

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