Department of Chest Medicine, Centre Hospitalier Universitaire UCL Namur, Université Catholique de Louvain, Yvoir, Belgium.
Department of Biostatistics and Evidence-Based Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
J Allergy Clin Immunol Pract. 2018 Jul-Aug;6(4):1274-1286.e9. doi: 10.1016/j.jaip.2017.09.002. Epub 2017 Oct 7.
Allergic rhinitis (AR) is increasingly acknowledged as having a substantial socioeconomic impact associated with impaired work productivity, although available information remains fragmented.
This systematic review summarizes recently available information to provide a quantitative estimate of the burden of AR on work productivity including lost work time (ie, absenteeism) and reduced performance while working (ie, presenteeism).
A Medline search retrieved original studies from 2005 to 2015 pertaining to the impact of AR on work productivity. A pooled analysis of results was carried out with studies reporting data collected through the validated Work Productivity and Activity Impairment (WPAI) questionnaire.
The search identified 19 observational surveys and 9 interventional studies. Six studies reported economic evaluations. Pooled analysis of WPAI-based studies found an estimated 3.6% (95% confidence interval [CI], 2.4; 4.8%) missed work time and 35.9% (95% CI, 29.7; 42.1%) had impairment in at-work performance due to AR. Economic evaluations indicated that indirect costs associated with lost work productivity are the principal contributor to the total AR costs and result mainly from impaired presenteeism. The severity of AR symptoms was the most consistent disease-related factor associated with a greater impact of AR on work productivity, although ocular symptoms and sleep disturbances may independently affect work productivity. Overall, the pharmacologic treatment of AR showed a beneficial effect on work productivity.
This systematic review provides summary estimates of the magnitude of work productivity impairment due to AR and identifies its main determinant factors. This information may help guide both clinicians and health policy makers.
过敏性鼻炎（AR）的社会经济影响日益受到关注，与工作生产效率下降有关，尽管现有信息仍然较为零散。
本系统综述总结了最新的相关信息，定量评估 AR 对工作生产效率的影响，包括工作时间损失（即旷工）和工作时的工作效率降低（即出勤但工作效率低下）。
通过 Medline 检索 2005 年至 2015 年与 AR 对工作生产效率影响相关的原始研究。通过对报告使用经过验证的工作生产效率和活动障碍（WPAI）问卷收集数据的研究进行汇总分析。
检索确定了 19 项观察性调查研究和 9 项干预性研究。6 项研究报告了经济评估结果。基于 WPAI 的汇总分析发现，AR 导致旷工的估计比例为 3.6%（95%置信区间 [CI]，2.4%4.8%），工作时生产效率下降的比例为 35.9%（95% CI，29.7%42.1%）。经济评估表明，与工作生产效率损失相关的间接成本是 AR 总费用的主要构成部分，主要源于出勤但工作效率低下。AR 症状的严重程度是与 AR 对工作生产效率影响更大最一致的疾病相关因素，但眼部症状和睡眠障碍也可能独立影响工作生产效率。总体而言，AR 的药物治疗对工作生产效率有有益影响。
本系统综述提供了 AR 导致工作生产效率下降的严重程度的汇总估计，并确定了其主要决定因素。这些信息可能有助于指导临床医生和卫生政策制定者。
