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创伤后应激障碍的药物治疗:超越指南

Pharmacotherapy of post-traumatic stress disorder: going beyond the guidelines.

作者信息

Davidson Jonathan

机构信息

, MB, BS, FRCPsych, Department of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.

出版信息

BJPsych Open. 2016 Nov 16;2(6):e16-e18. doi: 10.1192/bjpo.bp.116.003707. eCollection 2016 Nov.

DOI:10.1192/bjpo.bp.116.003707
PMID:29018563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5609778/
Abstract

SUMMARY

This article discusses the study of Harpaz-Rotem and associates, who examined patterns of medication use in first-diagnosed veterans with post-traumatic stress disorder (PTSD). It considers the difference between practice guidelines and actual prescribing; selectively identifies issues with antidepressants, antipsychotics, benzodiazepines and prazosin; and reviews the possible impact of new medications in the pipeline.

DECLARATION OF INTERESTS

In the past 36 months, J.D. has received compensation for consulting with Edgemont, Turing and Tonix Pharmaceuticals; royalties in connection with publications by Springer, Guilford and McFarland Publishers and use of the Connor-Davidson Resilience Scale, Davidson Trauma Scale, Social Phobia Inventory (SPIN) and Mini-SPIN; service on the INTRuST Data Safety and Monitoring Board, University of California, San Diego.

COPYRIGHT AND USAGE

© The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

摘要

摘要

本文讨论了哈帕兹 - 罗特姆及其同事的研究,他们调查了首次诊断为创伤后应激障碍(PTSD)的退伍军人的用药模式。文中考虑了实践指南与实际处方之间的差异;选择性地指出了抗抑郁药、抗精神病药、苯二氮䓬类药物和哌唑嗪存在的问题;并回顾了正在研发的新药可能产生的影响。

利益声明

在过去36个月里,J.D.已获得与埃奇蒙特、图灵和托尼克斯制药公司咨询相关的报酬;因施普林格、吉尔福德和麦克法兰出版社出版的著作以及使用康纳 - 戴维森复原力量表、戴维森创伤量表、社交恐惧症量表(SPIN)和迷你社交恐惧症量表(Mini - SPIN)而获得版税;曾在加利福尼亚大学圣地亚哥分校的INTRuST数据安全与监测委员会任职。

版权与使用

©英国皇家精神科医学院2016年。这是一篇开放获取文章,根据知识共享非商业性、禁止演绎(CC BY - NC - ND)许可协议发布。

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本文引用的文献

1
Initiation of pharmacotherapy for post-traumatic stress disorder among veterans from Iraq and Afghanistan: a dimensional, symptom cluster approach.伊拉克和阿富汗退伍军人创伤后应激障碍的药物治疗启动:一种维度、症状群方法
BJPsych Open. 2016 Sep 9;2(5):286-293. doi: 10.1192/bjpo.bp.115.002451. eCollection 2016 Sep.
2
Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial.喹硫平单药治疗创伤后应激障碍的疗效:一项随机、安慰剂对照试验。
Am J Psychiatry. 2016 Dec 1;173(12):1205-1212. doi: 10.1176/appi.ajp.2016.15070967. Epub 2016 Jul 15.
3
Treatment Options for Veterans With Posttraumatic Stress Disorder-Reply.
JAMA Psychiatry. 2016 Jul 1;73(7):757-8. doi: 10.1001/jamapsychiatry.2016.0573.
4
Treatment Options for Veterans With Posttraumatic Stress Disorder-Reply.创伤后应激障碍退伍军人的治疗选择——回复
JAMA Psychiatry. 2016 Jul 1;73(7):758. doi: 10.1001/jamapsychiatry.2016.0572.
5
Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis.创伤后应激障碍的药物治疗:系统评价和荟萃分析。
Br J Psychiatry. 2015 Feb;206(2):93-100. doi: 10.1192/bjp.bp.114.148551.
6
Vintage treatments for PTSD: a reconsideration of tricyclic drugs.创伤后应激障碍的传统疗法:三环类药物的再思考
J Psychopharmacol. 2015 Mar;29(3):264-9. doi: 10.1177/0269881114565143. Epub 2015 Jan 13.
7
Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology.焦虑障碍、创伤后应激障碍和强迫症的基于证据的药物治疗:英国心理药理学协会 2005 年指南的修订版。
J Psychopharmacol. 2014 May;28(5):403-39. doi: 10.1177/0269881114525674. Epub 2014 Apr 8.
8
A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan.一项针对从伊拉克和阿富汗返回的现役士兵创伤后应激障碍伴噩梦的普萘洛尔治疗试验。
Am J Psychiatry. 2013 Sep;170(9):1003-10. doi: 10.1176/appi.ajp.2013.12081133.
9
Prescribing trends in veterans with posttraumatic stress disorder.创伤后应激障碍退伍军人的处方趋势。
J Clin Psychiatry. 2012 Mar;73(3):297-303. doi: 10.4088/JCP.11m07311.
10
Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence.去甲肾上腺素能与 5-羟色胺能抗抑郁药联合或不联合纳曲酮用于 PTSD 合并酒精依赖的退伍军人。
Neuropsychopharmacology. 2012 Mar;37(4):996-1004. doi: 10.1038/npp.2011.283. Epub 2011 Nov 16.