To L B, Dyson P G, Branford A L, Russell J A, Haylock D N, Ho J Q, Kimber R J, Juttner C A
Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, Australia.
Bone Marrow Transplant. 1987 Jun;2(1):103-8.
Haemopoietic reconstitution was achieved in a patient with acute non-lymphoblastic leukaemia (ANLL) in relapse who was autografted with blood-derived stem cells collected during very early remission. The patient received a myeloid progenitor cell dose of 230 x 10(4) CFU-GM/kg body weight. Engraftment was evident in the bone marrow 7 days post-graft. Normal neutrophil and platelet counts were attained by day 14 and blood counts remained normal thereafter. An overshoot in peripheral blood haemopoietic progenitor levels occurred at the end of the second week, presumably the progeny of a family of early progenitor cells. The completeness of haemopoietic reconstitution is further illustrated by the satisfactory nucleated cell and myeloid progenitor cell yield when a bone marrow harvest was performed 4 1/2 months post-graft. Seven months post-graft, the patient remained in complete remission with normal blood counts and bone marrow cellularity, although haemopoietic progenitor levels were slightly reduced. The rapid recovery minimises aplasia-related risks and suggests that such autografting can be carried out safely in first remission. We propose that autografting using very early remission blood cells is a new therapeutic option for patients with acute ANLL.
一名急性非淋巴细胞白血病（ANLL）复发患者通过移植在极早期缓解期采集的血液来源干细胞实现了造血重建。该患者接受的髓系祖细胞剂量为230×10⁴ CFU - GM/千克体重。移植后7天骨髓中可见植入迹象。第14天中性粒细胞和血小板计数恢复正常，此后血细胞计数一直保持正常。第二周结束时外周血造血祖细胞水平出现过冲，推测是一族早期祖细胞的后代。移植后4个半月进行骨髓采集时，有核细胞和髓系祖细胞产量令人满意，进一步说明了造血重建的完整性。移植后7个月，患者仍处于完全缓解状态，血细胞计数和骨髓细胞构成正常，尽管造血祖细胞水平略有降低。快速恢复将再生障碍相关风险降至最低，表明这种自体移植可以在首次缓解期安全进行。我们提出，使用极早期缓解期血细胞进行自体移植是急性ANLL患者的一种新治疗选择。
