双向终止子：基因调控中一个被低估的方面。

Bidirectional terminators: an underestimated aspect of gene regulation.

作者信息

Robert François

机构信息

Institut de recherches cliniques de Montréal (IRCM), 110 Avenue des Pins Ouest, Montréal, QC, H2W 1R7, Canada.

Département de Médecine, Faculté de Médecine, Université de Montréal, 2900 Boulevard Edouard-Montpetit, Montréal, QC, H3T 1J4, Canada.

出版信息

Curr Genet. 2018 Apr;64(2):389-391. doi: 10.1007/s00294-017-0763-y. Epub 2017 Oct 10.

DOI:10.1007/s00294-017-0763-y

PMID:29018946

Abstract

Recent experimental and computational work revealed that transcriptional terminators in Saccharomyces cerevisiae can terminate transcription coming from both directions. This mechanism helps budding yeast cope with the pervasive nature of transcription by limiting aberrant transcription from invading neighboring genes.

摘要

最近的实验和计算工作表明，酿酒酵母中的转录终止子可以终止来自两个方向的转录。这种机制通过限制异常转录侵入邻近基因，帮助出芽酵母应对转录的普遍性。