Department of Psychology, Catholic University, Largo Agostino Gemelli 1, 20123, Milan, Italy.
Center for Medicine of the Aging, Policlinico Gemelli Foundation, Rome, Italy.
Aging Clin Exp Res. 2018 Jul;30(7):877-880. doi: 10.1007/s40520-017-0838-0. Epub 2017 Oct 11.
Parkinson's disease (PD) typically occurs in elderly people and some degree of cognitive impairment is usually present. Cognitive reserve (CR) theory was proposed to explain the discrepancy between the degree of brain pathologies and clinical manifestations. We administered a comprehensive neuropsychological battery to 35 non-demented participants affected by PD. All participants underwent also the Cognitive Reserve Index questionnaire and the Brief Intelligence Test as proxies for CR. Relationships between CR and cognitive performance were investigated by linear regression analyses, adjusting for significant confounding factors. At linear regression analyses, higher CR scores were independently associated with a better performance on Word Fluency (p ≤ 0.04) and Digit Span (backward) (p ≤ 0.02); no associations were observed between CR and other cognitive tests. Our data provide empirical support to the relation between CR and cognitive impairment in PD. In particular, this study suggests that CR may have greater effects on the cognitive areas mostly affected in PD as executive functions.
帕金森病（PD）通常发生在老年人中，并且通常存在一定程度的认知障碍。认知储备（CR）理论被提出用于解释脑病理学程度和临床表现之间的差异。我们对 35 名受 PD 影响的非痴呆参与者进行了全面的神经心理学测试。所有参与者还接受了认知储备指数问卷和简短智力测验，作为 CR 的代表。通过线性回归分析，调整了显著的混杂因素，研究了 CR 与认知表现之间的关系。在线性回归分析中，较高的 CR 得分与词语流畅性（p≤0.04）和数字跨度（向后）（p≤0.02）的表现更好独立相关;CR 与其他认知测试之间没有关联。我们的数据为 CR 与 PD 认知障碍之间的关系提供了经验支持。特别是，这项研究表明，CR 可能对执行功能等受 PD 影响最大的认知领域产生更大的影响。
