a Department of Chemistry-Biochemistry, Physics , University of Québec , C. P. 500, Trois-Rivières , Québec G9A 5H7 , Canada.
J Biomol Struct Dyn. 2018 Oct;36(13):3487-3495. doi: 10.1080/07391102.2017.1391124. Epub 2017 Oct 23.
Dietary polyphenols are abundant micronutrients in our diet and paly major role in prevention of degenerative diseases. The binding efficacy of antioxidant polyphenols resveratrol, genistein, and curcumin with PAMAM-G3 and PAMAM-G4 nanoparticles was investigated in aqueous solution at physiological conditions, using multiple spectroscopic methods, TEM images, and docking studies. The polyphenol bindings are via hydrophilic, hydrophobic, and H-bonding contacts with resveratrol forming more stable conjugates. As PAMAM size increased the loading efficacy and the stability of polyphenol-polymer conjugates were increased. Polyphenol binding induced major alterations of dendrimer morphology. PAMAM nanoparticles are capable of delivery of polyphenols in vitro.
饮食中的多酚类化合物是我们饮食中的丰富微量营养素，在预防退行性疾病方面发挥着重要作用。在生理条件下，使用多种光谱方法、TEM 图像和对接研究，研究了抗氧化多酚白藜芦醇、染料木黄酮和姜黄素与 PAMAM-G3 和 PAMAM-G4 纳米粒子在水溶液中的结合效力。多酚类化合物的结合是通过亲水、疏水和氢键与白藜芦醇形成更稳定的共轭物。随着 PAMAM 尺寸的增加，多酚-聚合物缀合物的载药效率和稳定性增加。多酚结合诱导树枝状大分子形态的主要变化。PAMAM 纳米粒子能够在体外递送多酚类化合物。
