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直肠癌治疗中低位前切除综合征的病理生理方面

Pathophysiological aspects of the low anterior resection syndrome for treatment of rectal cancer.

作者信息

Buzatti Kelly Cristine de Lacerda Rodrigues, Petroianu Andy

机构信息

Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG), Instituto Alfa de Gastrenterologia, Belo Horizonte, MG, Brasil.

Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Departamento de Cirurgia, Belo Horizonte, MG, Brasil.

出版信息

Rev Col Bras Cir. 2017 Jul-Aug;44(4):397-402. doi: 10.1590/0100-69912017004003.

DOI:10.1590/0100-69912017004003
PMID:29019544
Abstract

The number of patients with bowel dysfunction due to the treatment of rectal cancer has increased during the recent decades. Anatomical and functional disorders after the removal of the rectum are followed by increased stool frequency, urgency, multiple evacuations and flatus or stool incontinence characterizing the low anterior resection syndrome - LARS. The purpose of this article is to present a review of the literature on current concepts and pathophysiological aspects of bowel dysfunction after resection of rectal cancer. It is essential to understand these mechanisms for a better management of patients and recovery of their quality of life.

摘要

近几十年来,因直肠癌治疗导致肠道功能障碍的患者数量有所增加。直肠切除术后的解剖和功能紊乱会导致排便频率增加、便急、多次排便以及排气或大便失禁,这些都是低位前切除综合征(LARS)的特征。本文的目的是对有关直肠癌切除术后肠道功能障碍的当前概念和病理生理方面的文献进行综述。了解这些机制对于更好地管理患者和恢复他们的生活质量至关重要。

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Pathophysiological aspects of the low anterior resection syndrome for treatment of rectal cancer.直肠癌治疗中低位前切除综合征的病理生理方面
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Updates Surg. 2025 Jul 9. doi: 10.1007/s13304-025-02320-z.
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Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial.褪黑素对低位前切除综合征患者的影响(MELLARS):一项随机、安慰剂对照、交叉试验的研究方案。
BMJ Open. 2023 Sep 11;13(9):e067763. doi: 10.1136/bmjopen-2022-067763.
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Machine learning model for prediction of low anterior resection syndrome following laparoscopic anterior resection of rectal cancer: A multicenter study.
机器学习模型预测腹腔镜直肠癌前切除术术后低位前切除综合征:一项多中心研究。
World J Gastroenterol. 2023 May 21;29(19):2979-2991. doi: 10.3748/wjg.v29.i19.2979.
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Anorectal dysfunction in patients with mid-low rectal cancer after surgery: A pilot study with three-dimensional high-resolution manometry.中低位直肠癌患者术后的肛门直肠功能障碍:一项三维高分辨率测压法的初步研究
World J Clin Cases. 2022 Apr 26;10(12):3754-3763. doi: 10.12998/wjcc.v10.i12.3754.
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The incidence and risk factors of low anterior resection syndrome (LARS) after sphincter-preserving surgery of rectal cancer: a systematic review and meta-analysis.直肠癌保肛手术后低位前切除综合征(LARS)的发生率及相关风险因素:系统评价与荟萃分析。
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