Livingston Melvin D, Barnett Tracey E, Delcher Chris, Wagenaar Alexander C
Melvin D. Livingston is with the Department of Biostatistics and Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth. Tracey E. Barnett is with the Department of Health Behavior and Health Systems, School of Public Health, University of North Texas Health Science Center. Chris Delcher is with the Department of Health Outcomes and Policy, College of Medicine, University of Florida, Gainesville. Alexander C. Wagenaar is with the Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA.
Am J Public Health. 2017 Nov;107(11):1827-1829. doi: 10.2105/AJPH.2017.304059.
To examine the association between Colorado's legalization of recreational cannabis use and opioid-related deaths.
We used an interrupted time-series design (2000-2015) to compare changes in level and slope of monthly opioid-related deaths before and after Colorado stores began selling recreational cannabis. We also describe the percent change in opioid-related deaths by comparing the unadjusted model-smoothed number of deaths at the end of follow-up with the number of deaths just prior to legalization.
Colorado's legalization of recreational cannabis sales and use resulted in a 0.7 deaths per month (b = -0.68; 95% confidence interval = -1.34, -0.03) reduction in opioid-related deaths. This reduction represents a reversal of the upward trend in opioid-related deaths in Colorado.
Legalization of cannabis in Colorado was associated with short-term reductions in opioid-related deaths. As additional data become available, research should replicate these analyses in other states with legal recreational cannabis.
研究科罗拉多州娱乐用大麻合法化与阿片类药物相关死亡之间的关联。
我们采用中断时间序列设计（2000 - 2015年），比较科罗拉多州商店开始销售娱乐用大麻前后每月阿片类药物相关死亡的水平和斜率变化。我们还通过比较随访结束时未经调整的模型平滑死亡人数与合法化前的死亡人数，描述阿片类药物相关死亡的百分比变化。
科罗拉多州娱乐用大麻销售和使用的合法化导致阿片类药物相关死亡每月减少0.7例（b = -0.68；95%置信区间 = -1.34，-0.03）。这一减少代表了科罗拉多州阿片类药物相关死亡上升趋势的逆转。
科罗拉多州大麻合法化与阿片类药物相关死亡的短期减少有关。随着更多数据可用，研究应在其他娱乐用大麻合法化的州重复这些分析。
