Ding Lei, Wo Like, Du Zhongyan, Tang Lihua, Song Zhenyuan, Dou Xiaobing
College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, P. R. China.
Zhejiang Provincial Hospital of Traditional Chinese Medical, Hangzhou, P. R. China.
PLoS One. 2017 Oct 11;12(10):e0186357. doi: 10.1371/journal.pone.0186357. eCollection 2017.
Alcoholic liver disease (ALD) is a type of chronic liver disease caused by long-term heavy ethanol consumption. Danshen is one of the most commonly used substances in traditional Chinese medicine and has been widely used for the treatment of various diseases, and most frequently, the ALD. The current study aims to determine the potential beneficial effect of Danshen administration on ALD and to clarify the underlying molecular mechanisms. Danshen administration improved liver pathologies of ALD, attenuated alcohol-induced increment of hepatic 4-Hydroxynonenal (4-HNE) formation, and prevented hepatic Peroxisome proliferators activated receptor alpha (PPARα) suppression in response to chronic alcohol consumption. Cell culture studies revealed that both hepatoprotective effect and increased intracellular 4-HNE clearance instigated by Danshen supplementation are PPARα-dependent. In conclusion, Danshen administration can protect against ALD via inducing PPARα activation and subsequent 4-HNE degradation.
酒精性肝病（ALD）是一种由长期大量饮用乙醇引起的慢性肝病。丹参是中药中最常用的药材之一，已被广泛用于治疗各种疾病，其中最常见的是酒精性肝病。本研究旨在确定丹参给药对酒精性肝病的潜在有益作用，并阐明其潜在的分子机制。丹参给药改善了酒精性肝病的肝脏病理，减轻了酒精诱导的肝脏4-羟基壬烯醛（4-HNE）生成增加，并防止了慢性酒精摄入引起的肝脏过氧化物酶体增殖物激活受体α（PPARα）抑制。细胞培养研究表明，丹参补充剂所激发的肝保护作用和细胞内4-HNE清除增加均依赖于PPARα。总之，丹参给药可通过诱导PPARα激活和随后的4-HNE降解来预防酒精性肝病。
