Ayres Andréia Rodrigues Gonçalves, Silva Gulnar Azevedo E, Teixeira Maria Teresa Bustamante, Duque Kristiane de Castro Dias, Machado Maria Lúcia Salim Miranda, Gamarra Carmen Justina, Levi José Eduardo
Hospital Universitário Gaffrée e Guinle. Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Departamento de Epidemiologia. Instituto de Medicina Social. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Rev Saude Publica. 2017 Oct 5;51:92. doi: 10.11606/S1518-8787.2017051000065.
Estimate the prevalence of cervical HPV infection among women assisted by the Family Health Strategy and identify the factors related to the infection.
A cross-sectional study involving 2,076 women aged 20-59 years old residing in Juiz de Fora, State of Minas Gerais, who were asked to participate in an organized screening carried out in units were the Family Health Strategy had been implemented. Participants answered the standardized questionnaire and underwent a conventional cervical cytology test and HPV test for high oncogenic risk. Estimates of HPV infection prevalence were calculated according to selected characteristics referenced in the literature and related to socioeconomic status, reproductive health and lifestyle.
The overall prevalence of HPV infection was 12.6% (95%CI 11.16-14.05). The prevalence for the pooled primer contained 12 oncogenic HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) was 8.6% (95%CI 7.3-9.77). In the multivariate analysis, it was observed that the following variables were significantly associated with a higher prevalence of HPV infection: marital status (single: adjusted PR = 1.40, 95%CI 1.07-1.8), alcohol consumption (any lifetime frequency: adjusted PR = 1.44, 95%CI 1.11-1.86) and number of lifetime sexual partners (≥ 3: adjusted PR = 1.35, 95%CI 1.04-1.74).
The prevalence of HPV infection in the study population ranges from average to particularly high among young women. The prevalence of HPV16 and HPV18 infection is similar to the worldwide prevalence. Homogeneous distribution among the pooled primer types would precede the isolated infection by HPV18 in magnitude, which may be a difference greater than the one observed. The identification of high-risk oncogenic HPV prevalence may help identify women at higher risk of developing preneoplastic lesions.
评估家庭健康战略所服务女性中宫颈人乳头瘤病毒（HPV）感染的患病率，并确定与该感染相关的因素。
一项横断面研究，涉及居住在米纳斯吉拉斯州茹伊斯迪福拉市的2076名年龄在20至59岁之间的女性，她们被邀请参加在已实施家庭健康战略的单位中开展的有组织筛查。参与者回答了标准化问卷，并接受了传统宫颈细胞学检查和高危致癌风险HPV检测。根据文献中提及的、与社会经济地位、生殖健康和生活方式相关的选定特征，计算HPV感染患病率的估计值。
HPV感染的总体患病率为12.6%（95%置信区间11.16 - 14.05）。包含12种致癌HPV类型（31、33、35、39、45、51、52、56、58、59、66和68）的混合引物的患病率为8.6%（95%置信区间7.3 - 9.77）。在多变量分析中，观察到以下变量与HPV感染的较高患病率显著相关：婚姻状况（单身：调整后风险比 = 1.40，95%置信区间1.07 - 1.8）、饮酒情况（任何终生频率：调整后风险比 = 1.44，95%置信区间1.11 - 1.86）以及终生性伴侣数量（≥3：调整后风险比 = 1.35，95%置信区间1.04 - 1.74）。
研究人群中HPV感染的患病率在年轻女性中处于中等至特别高的范围。HPV16和HPV18感染的患病率与全球患病率相似。混合引物类型中的均匀分布在数量上先于HPV18的单独感染，这可能是一个比观察到的差异更大的差异。确定高危致癌HPV的患病率可能有助于识别发生癌前病变风险较高的女性。
