中国四川省人乳头瘤病毒（HPV）流行特征

Characteristics of HPV prevalence in Sichuan Province, China.

作者信息

Chen Zuyi, Wang Qingming, Ding Xianping, Li Qiongyao, Zhong Rong, Ren Huaying

机构信息

Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, Sichuan University, Chengdu, China; Bio-Resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Sichuan and Chongqing, China; Institute of Medical Genetics, College of Life Science, Sichuan University, Chengdu, China.

出版信息

Int J Gynaecol Obstet. 2015 Dec;131(3):277-80. doi: 10.1016/j.ijgo.2015.06.027. Epub 2015 Sep 6.

DOI:10.1016/j.ijgo.2015.06.027

PMID:26391672

Abstract

OBJECTIVE

To investigate the distribution of HPV subtypes and analyze variation in infection trends during a 6-year period in Sichuan Province, China.

METHODS

A cross-sectional observational study was conducted at a center in Chengdu between January 1, 2009, and December 31, 2014. Patients with at least one type of cervical disease confirmed by histology and cytology were eligible for inclusion. Cervical specimens were tested for the presence of high-risk and low-risk HPV subtypes by reverse membrane hybridization.

RESULTS

Among 10 682 participants, 3370 women (31.5%) were infected with HPV. The most frequently detected high-risk genotypes were HPV16 (n=791; 27.1%), HPV58 (n=476; 16.3%), HPV33 (n=273; 9.4%), HPV52 (n=244; 8.4%), and HPV18 (n=201; 6.9%). The most frequently detected low-risk genotype was HPV6 (n=703; 40.8%). The detection rates of HPV33 (from 7.9% to 10.2%) and HPV58 (from 14.0% to 16.7%) increased over the 6-year period, whereas those of HPV16 (from 32.3% to 24.9%) and HPV18 (from 10.0% to 6.2%) decreased. The prevalence of HPV infection was highest among women aged 21-25 years (χ(2)=191.189; P<0.001).

CONCLUSION

HPV58 and HPV33 were the most prevalent subtypes in Sichuan. Changes in the prevalences of infection with different HPV subtypes have been identified.

摘要

目的

调查中国四川省人乳头瘤病毒（HPV）亚型分布情况，并分析6年间感染趋势的变化。

方法

于2009年1月1日至2014年12月31日在成都某中心开展一项横断面观察性研究。经组织学和细胞学确诊至少患有一种宫颈疾病的患者纳入研究。采用反向膜杂交法检测宫颈标本中高危型和低危型HPV亚型。

结果

10682名参与者中，3370名女性（31.5%）感染HPV。最常检测到的高危基因型为HPV16（n = 791；27.1%）、HPV58（n = 476；16.3%）、HPV33（n = 273；9.4%）、HPV52（n = 244；8.4%）和HPV18（n = 201；6.9%）。最常检测到的低危基因型为HPV6（n = 703；40.8%）。6年间，HPV33（从7.9%升至10.2%）和HPV58（从14.0%升至16.7%）的检出率上升，而HPV16（从32.3%降至24.9%）和HPV18（从10.0%降至6.2%）的检出率下降。HPV感染率在21 - 25岁女性中最高（χ(2)=191.189；P<0.001）。