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新方法提示短疗程抗生素治疗腹腔内感染具有全球优势。

Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections.

机构信息

Department of Surgery, Beth Israel Deaconess Medical Center.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

出版信息

Clin Infect Dis. 2017 Oct 16;65(9):1577-1579. doi: 10.1093/cid/cix569.

DOI:10.1093/cid/cix569
PMID:29020201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5850039/
Abstract

Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.

摘要

结局偏好评分和基于抗生素持续时间的应答调整（DOOR/RADAR）是评估抗生素试验数据的新颖创新方法。我们分析了短程抗菌治疗腹腔内感染（STOP-IT）非劣效性试验的数据，结果表明短疗程治疗腹腔内感染具有整体优越性。

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Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections.新方法提示短疗程抗生素治疗腹腔内感染具有全球优势。
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本文引用的文献

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Using Outcomes to Analyze Patients Rather than Patients to Analyze Outcomes: A Step toward Pragmatism in Benefit:risk Evaluation.利用结果分析患者而非利用患者分析结果：迈向效益-风险评估实用主义的一步。
Stat Biopharm Res. 2016;8(4):386-393. doi: 10.1080/19466315.2016.1207561. Epub 2016 Dec 6.
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Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR).结果排名的可取性（DOOR）和根据抗生素风险持续时间调整的反应（RADAR）。
Clin Infect Dis. 2015 Sep 1;61(5):800-6. doi: 10.1093/cid/civ495. Epub 2015 Jun 25.
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Trial of short-course antimicrobial therapy for intraabdominal infection.腹腔内感染短程抗菌治疗试验
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Current issues in non-inferiority trials.非劣效性试验中的当前问题。
Stat Med. 2008 Feb 10;27(3):317-32. doi: 10.1002/sim.2855.
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Risk factors for Clostridium difficile infection.艰难梭菌感染的危险因素。
J Hosp Infect. 1998 Sep;40(1):1-15. doi: 10.1016/s0195-6701(98)90019-6.