热带地区眼弓形体病：一项多中心合作研究的 190 例患者分析和结局。

Ocular Toxoplasmosis in Tropical Areas: Analysis and Outcome of 190 Patients from a Multicenter Collaborative Study.

机构信息

a National Healthcare Group Eye Institute , Tan Tock Seng Hospital , Singapore , Singapore.

b Department of Ophthalmology , Faculdade de Medicina and Hospital São Geraldo/Hospital das Clínicas da Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

出版信息

Ocul Immunol Inflamm. 2018;26(8):1289-1296. doi: 10.1080/09273948.2017.1367407. Epub 2017 Oct 11.

DOI:10.1080/09273948.2017.1367407

PMID:29020481

Abstract

PURPOSE

To describe clinical findings and outcomes for ocular toxoplasmosis in an international multicenter collaborative study.

METHODS

Retrospective analysis of 190 patients diagnosed with ocular toxoplasmosis from three study sites (Brazil, India, and Singapore).

RESULTS

There were 93 (48.9%) females with a mean age of 32.8 years. The most common symptoms were isolated blurring of vision (36.8%), followed by blurring of vision with floaters (21.1%). Treatment regimens varied largely from monotherapy to multiple combination therapies. Final visual acuity of ≥20/40 was achieved in 106 (74.2%) patients. In a median follow-up period of 31 weeks (range 12-749 weeks), 83/190 (43.7%) patients suffered a relapse.

CONCLUSIONS

There appears to be geographical variation in the presentation of ocular toxoplasmosis. Compared to previous studies, we did not observe the '"dual peak" phenomenon of chronic and active disease based on age at presentation, and there was less bilateral and macular involvement (but more peripheral involvement).

摘要

目的

描述一项国际多中心合作研究中眼弓形体病的临床发现和结局。

方法

对来自三个研究地点（巴西、印度和新加坡）的 190 例诊断为眼弓形体病的患者进行回顾性分析。

结果

93 例（48.9%）为女性，平均年龄为 32.8 岁。最常见的症状是孤立的视力模糊（36.8%），其次是伴有飞蚊症的视力模糊（21.1%）。治疗方案差异很大，从单一疗法到多种联合疗法。106 例（74.2%）患者最终视力达到≥20/40。在 31 周的中位随访期（12-749 周）内，83/190（43.7%）例患者复发。