Arikapudi Sowminya, Rashid Saima, Al Almomani Laith Adel, Treece Jennifer, Baumrucker Steven J
1 Department of Internal Medicine, East Tennessee State University, Johnson City, TN, USA.
2 Department of Hospice and Palliative Medicine, Wellmont Health System, Kingsport, TN, USA.
Am J Hosp Palliat Care. 2018 May;35(5):814-817. doi: 10.1177/1049909117735831. Epub 2017 Oct 11.
Cancer treatments including chemotherapy and radiotherapy treat cancer by targeting rapidly dividing cells. Although these forms of treatment damage rapidly dividing cancer cells, they are also toxic to the cells of the gastrointestinal tract, leading to inflammation of the mucosal layer (mucositis) and causing nausea, vomiting, diarrhea, and abdominal pain. Improvement in symptoms may allow patients to have better performance status permitting ongoing treatment and possibly a better prognosis. This article describes the pathophysiology of chemotherapy-induced mucositis and includes 3 case reports of treatment of mucositis with serum bovine immunoglobulin.
包括化疗和放疗在内的癌症治疗方法是通过靶向快速分裂的细胞来治疗癌症的。尽管这些治疗方式会损害快速分裂的癌细胞，但它们对胃肠道细胞也有毒性，会导致黏膜层炎症（黏膜炎），并引起恶心、呕吐、腹泻和腹痛。症状的改善可能会使患者有更好的身体状况，从而能够继续接受治疗，并可能有更好的预后。本文描述了化疗引起的黏膜炎的病理生理学，并包括3例用牛血清免疫球蛋白治疗黏膜炎的病例报告。
