Heart and Lung Institute, The Prince Charles Hospital, Brisbane, QLD
The George Institute for Global Health, Sydney, NSW.
Med J Aust. 2017 Oct 16;207(8):357-361. doi: 10.5694/mja16.01134.
Introduction This article summarises the Cardiac Society of Australia and New Zealand position statement on coronary artery calcium (CAC) scoring. CAC scoring is a non-invasive method for quantifying coronary artery calcification using computed tomography. It is a marker of atherosclerotic plaque burden and the strongest independent predictor of future myocardial infarction and mortality. CAC scoring provides incremental risk information beyond traditional risk calculators such as the Framingham Risk Score. Its use for risk stratification is confined to primary prevention of cardiovascular events, and can be considered as individualised coronary risk scoring for intermediate risk patients, allowing reclassification to low or high risk based on the score. Medical practitioners should carefully counsel patients before CAC testing, which should only be undertaken if an alteration in therapy, including embarking on pharmacotherapy, is being considered based on the test result. Main recommendations CAC scoring should primarily be performed on individuals without coronary disease aged 45-75 years (absolute 5-year cardiovascular risk of 10-15%) who are asymptomatic. CAC scoring is also reasonable in lower risk groups (absolute 5-year cardiovascular risk, < 10%) where risk scores traditionally underestimate risk (eg, family history of premature CVD) and in patients with diabetes aged 40-60 years. We recommend aspirin and a high efficacy statin in high risk patients, defined as those with a CAC score ≥ 400, or a CAC score of 100-399 and above the 75th percentile for age and sex. It is reasonable to treat patients with CAC scores ≥ 100 with aspirin and a statin. It is reasonable not to treat asymptomatic patients with a CAC score of zero. Changes in management as a result of this statement Cardiovascular risk is reclassified according to CAC score. High risk patients are treated with a high efficacy statin and aspirin. Very low risk patients (ie, CAC score of zero) do not benefit from treatment.
简介 本文总结了澳大利亚和新西兰心脏学会关于冠状动脉钙(CAC)评分的立场声明。CAC 评分是一种使用计算机断层扫描定量冠状动脉钙化的非侵入性方法。它是动脉粥样硬化斑块负担的标志物,也是未来心肌梗死和死亡的最强独立预测因素。CAC 评分提供了传统风险计算器(如弗雷明汉风险评分)之外的增量风险信息。其用于风险分层仅限于心血管事件的一级预防,可以考虑将其作为中间风险患者的个体化冠状动脉风险评分,根据评分将其重新分类为低风险或高风险。在进行 CAC 检测之前,医生应仔细向患者提供咨询,只有在考虑根据检测结果改变治疗方法,包括开始药物治疗时,才应进行 CAC 检测。主要建议 CAC 评分应主要在无冠心病、年龄在 45-75 岁(绝对 5 年心血管风险为 10-15%)、无症状的个体中进行。在风险评分传统上低估风险的低危人群(绝对 5 年心血管风险,<10%)和年龄在 40-60 岁的糖尿病患者中,CAC 评分也合理。我们建议在高危患者中使用阿司匹林和高效他汀类药物,高危患者定义为 CAC 评分≥400 或 CAC 评分 100-399,但年龄和性别处于第 75 百分位以上。对于 CAC 评分≥100 的患者,使用阿司匹林和他汀类药物治疗是合理的。对于 CAC 评分 0 的无症状患者,不进行治疗也是合理的。基于本声明的管理变化 根据 CAC 评分重新分类心血管风险。高危患者使用高效他汀类药物和阿司匹林治疗。极低危患者(即 CAC 评分 0)不会从治疗中获益。