Department of Gerontology and Geriatric Nursing, School of Health Sciences, Medical University of Silesia, 40-635 Katowice, Poland.
Department of Electrocardiology, Upper Silesian Medical Centre, 40-635 Katowice, Poland.
Int J Environ Res Public Health. 2019 Jun 16;16(12):2132. doi: 10.3390/ijerph16122132.
There is no consensus as to whether the Coronary Artery Calcium Score (CACS) results can affect the therapeutic approach that is selected for coronary artery disease. The aim of this study was to follow patients' management over a period of ten years after application of the CACS. : The research was conducted as a prospective, single-center, long-distance study. In 174 asymptomatic patients (78M; aged 58.9 ± 7.86), a CACS examination using 64-slice computed tomography was performed between 2008 and 2009. The patients were divided into three subgroups according to the CACS results using Agatston Units (AU)-G1: CACS = 0 AU (52 pts); G2: CACS = 1-399 AU (64 pts) and G3: CACS ≥ 400 AU (58 pts). During the ten years of follow-up, the classical cardiovascular risk factors, drugs, diseases, and information about the therapeutic approach that was used (PCI-Percutaneous Coronary Intervention; CABG-Coronary Artery Bypass Graft) were also analyzed. : The average time until a percutaneous intervention (PCI) was 825.2 ± 1111.7 and for CABG, it was 529.0 ± 833.6. PCI was performed in 5.8% (G1), 4.7% (G2) and 32.6% (G3) of the cases, respectively; = 0.0000. CABG was performed in 0% (G1), 1.6% (G2) and 18.9% (G3) of the cases, respectively; 0.0035 Yates. The area under the curve in PCI was 0.783 (95% CI: 0.714-0.841); in CABG, it was 0.825 (95% CI: 0.760-0.878) and the average for both groups was 0.838 (95% CI: 0.774-0.889). : The coronary artery calcium score can potentially help to predict the best therapeutic approach for coronary artery disease in a ten-year perspective.
目前，对于冠状动脉钙评分（CACS）结果是否会影响冠状动脉疾病的治疗方法选择，尚未达成共识。本研究旨在对 CACS 应用 10 年后患者的管理情况进行随访。
该研究为前瞻性、单中心、长距离研究。在 174 例无症状患者（78 例男性；年龄 58.9 ± 7.86 岁）中，于 2008 年至 2009 年期间使用 64 层计算机断层扫描进行 CACS 检查。根据 Agatston 单位（AU）的 CACS 结果，将患者分为三组：G1：CACS = 0 AU（52 例）；G2：CACS = 1-399 AU（64 例）；G3：CACS ≥ 400 AU（58 例）。在 10 年的随访期间，还分析了经典心血管危险因素、药物、疾病以及使用的治疗方法（PCI-经皮冠状动脉介入治疗；CABG-冠状动脉旁路移植术）的信息。
平均到行经皮介入（PCI）的时间为 825.2 ± 1111.7 天，行冠状动脉旁路移植术（CABG）的时间为 529.0 ± 833.6 天。分别有 5.8%（G1）、4.7%（G2）和 32.6%（G3）的患者接受了 PCI， = 0.0000。分别有 0%（G1）、1.6%（G2）和 18.9%（G3）的患者接受了 CABG， 0.0035 Yates。PCI 的曲线下面积为 0.783（95%CI：0.714-0.841）；CABG 的曲线下面积为 0.825（95%CI：0.760-0.878），两组的平均曲线下面积为 0.838（95%CI：0.774-0.889）。
冠状动脉钙评分可在 10 年的时间范围内，有助于预测冠状动脉疾病的最佳治疗方法。
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