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巴西年轻人中艾滋病毒感染患病率、发病率及危险因素的范围综述。

A scoping review of prevalence, incidence and risk factors for HIV infection amongst young people in Brazil.

作者信息

Saffier Igor Pedrosa, Kawa Hélia, Harling Guy

机构信息

Department of Epidemiology, Fluminense Federal University, Niterói, Brazil.

Institute for Global Health, University College London, Mortimer Market Centre, London, WC1E 6JB, UK.

出版信息

BMC Infect Dis. 2017 Oct 11;17(1):675. doi: 10.1186/s12879-017-2795-9.

Abstract

BACKGROUND

Despite young people being a key population for HIV prevention, the HIV epidemic amongst young Brazilians is perceived to be growing. We therefore reviewed all published literature on HIV prevalence and risk factors for HIV infection amongst 10-25 year olds in Brazil.

METHODS

We searched Embase, LILACS, Proquest, PsycINFO, PubMed, Scopus and Web of Science for studies published up to March 2017 and analyzed reference lists of relevant studies. We included published studies from any time in the HIV epidemic which provided estimates specific to ages 10-25 (or some subset of this age range) for Brazilians on either: (a) HIV prevalence or incidence; or (b) the association between HIV and socio-demographic or behavioral risk factors.

RESULTS

Forty eight publications met the inclusion criteria: 44 cross-sectional, two case-control, two cohort. Four studies analysed national data. Forty seven studies provided HIV prevalence estimates, largely for six population subgroups: Counselling and Testing Center attendees; blood donors; pregnant women; institutional individuals; men-who-have-sex-with-men (MSM) and female sex workers (FSW); four provided HIV incidence estimates. Twelve studies showed HIV status to be associated with a wide range of risk factors, including age, sexual and reproductive history, infection history, substance use, geography, marital status, mental health and socioeconomic status.

CONCLUSIONS

Few published studies have examined HIV amongst young people in Brazil, and those published have been largely cross-sectional and focused on traditional risk groups and the south of the country. Despite these limitations, the literature shows raised HIV prevalence amongst MSM and FSW, as well as amongst those using drugs. Time trends are harder to identify, although rates appear to be falling for pregnant women, possibly reversing an earlier de-masculinization of the epidemic. Improved surveillance of HIV incidence, prevalence and risk factors is a key component of efforts to eliminate HIV in Brazil.

摘要

背景

尽管年轻人是预防艾滋病病毒的关键人群,但巴西年轻人中的艾滋病病毒疫情被认为正在蔓延。因此,我们回顾了所有已发表的关于巴西10至25岁人群中艾滋病病毒流行率及感染风险因素的文献。

方法

我们检索了Embase、LILACS、Proquest、PsycINFO、PubMed、Scopus和Web of Science,查找截至2017年3月发表的研究,并分析了相关研究的参考文献列表。我们纳入了艾滋病病毒疫情期间任何时间发表的研究,这些研究提供了针对巴西10至25岁(或该年龄范围的某些子集)人群的以下方面的具体估计:(a)艾滋病病毒流行率或发病率;或(b)艾滋病病毒与社会人口统计学或行为风险因素之间的关联。

结果

48篇出版物符合纳入标准:44篇横断面研究、2篇病例对照研究、2篇队列研究。4项研究分析了全国数据。47项研究提供了艾滋病病毒流行率估计,主要针对6个人口亚组:咨询和检测中心参与者;献血者;孕妇;机构内人员;男男性行为者(MSM)和女性性工作者(FSW);4项提供了艾滋病病毒发病率估计。12项研究表明艾滋病病毒感染状况与多种风险因素相关,包括年龄、性和生殖史、感染史、物质使用、地理位置、婚姻状况、心理健康和社会经济地位。

结论

巴西针对年轻人中艾滋病病毒的已发表研究较少,且已发表的研究大多为横断面研究,主要集中在传统风险群体和该国南部地区。尽管存在这些局限性,但文献显示男男性行为者和女性性工作者以及吸毒者中的艾滋病病毒流行率有所上升。虽然孕妇的感染率似乎在下降,可能扭转了疫情早期的去男性化趋势,但时间趋势更难确定。加强对艾滋病病毒发病率、流行率和风险因素的监测是巴西消除艾滋病病毒努力的关键组成部分。

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