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巴西南部某一地区 HIV-1 感染以 C 型为主,该地区感染 HIV/AIDS 的孕妇的流行病学和临床特征。

Epidemiologic and clinical characteristics of pregnant women living with HIV/AIDS in a region of Southern Brazil where the subtype C of HIV-1 infection predominates.

机构信息

Laboratory of Immunology and Mutagenesis, Universidade do Extremo Sul Catarinense, Santa Catarina, Brazil.

出版信息

Braz J Infect Dis. 2011 Jul-Aug;15(4):349-55.

Abstract

UNLABELLED

Southern Brazil has the highest prevalence rate of AIDS in the country and is the only region in the Americas where HIV-1 subtype C prevails.

OBJECTIVE

We evaluated the epidemiologic and clinical characteristics of pregnant women living with HIV/AIDS in the South region of Santa Catarina, Brazil.

METHODS

All pregnant women with HIV infection attending the obstetric outpatient clinic of Criciúma, State of Santa Catarina, in 2007 (n = 46) were invited to participate. Data of 36 eligible participants were obtained through a standardized questionnaire.

RESULTS

The great majority were young, with a steady partner, low family income, low education level and referring early first sexual intercourse. Many reported use of illicit non-injecting drugs (55.5%) and unprotected sex with partners that were HIV-positive (57.7%), injecting drug user (22.2%), male inmate (19.4%), truck driver (13.8%), with history of sexually transmitted disease (11.1%) or men who have sex with men (MSM) (2.8%). Most (66.7%) of the participants had their HIV diagnosis done during the pregnancy, 7 (19.4%) had a previous history of HIV mother-to-child transmission. Therapy based on highly active antiretroviral therapy (94%) was initiated at 19.3 weeks on average and 33% showed irregular antiretroviral adherence.

CONCLUSION

These results confirm previous data on HIV epidemiology in Brazil and suggest that the women partners' sexual behavior and unprotected sexual intercourse are important aspects of HIV epidemic. Additional efforts in education, prophylaxis and medication adherence are needed.

摘要

目的

我们评估了巴西圣卡塔琳娜州南部地区感染 HIV/AIDS 的孕妇的流行病学和临床特征。

方法

邀请了 2007 年在圣卡塔琳娜州克里西乌马的妇产科门诊就诊的所有 HIV 感染孕妇参加研究(n=46)。通过标准化问卷获得了 36 名合格参与者的数据。

结果

绝大多数参与者是年轻的,有稳定的伴侣,家庭收入低,教育程度低,首次性行为较早。许多人报告说使用了非法的非注射类药物(55.5%),并且与 HIV 阳性(57.7%)、注射毒品使用者(22.2%)、男性囚犯(19.4%)、卡车司机(13.8%)、有性传播疾病史(11.1%)或男男性接触者(MSM)(2.8%)的性伴侣发生了无保护的性行为。大多数(66.7%)参与者在怀孕期间被诊断出 HIV,7(19.4%)有 HIV 母婴传播的既往史。平均在 19.3 周时开始基于高效抗逆转录病毒治疗的治疗,33%的人显示出不规则的抗逆转录病毒药物依从性。

结论

这些结果证实了巴西 HIV 流行病学的先前数据,并表明女性伴侣的性行为和无保护的性行为是 HIV 流行的重要方面。需要进一步努力开展教育、预防和药物依从性。

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