Instituto de Saúde Coletiva, Universidade Federal da Bahia, R. Basílio da Gama, s/n - Canela, Salvador, BA, CEP: 40110-040, Brazil.
Departmento de Ciências da Vida, Universidade Estadual da Bahia, Salvador, Brazil.
BMC Public Health. 2022 Sep 12;22(1):1728. doi: 10.1186/s12889-022-14134-4.
Adolescent men who have sex with men (aMSM) and transgender women (aTGW) are affected disproportionately by human immunodeficiency virus (HIV) infection. Although new methods of pre-exposure prophylaxis (PrEP), such as long-acting injectable (LAI-PrEP), have been approved by the Food and Drug Administration, their acceptability among aMSM/aTGW is not well known.
Forty-eight semi-structured interviews were conducted to assess the knowledge and interest in LAI-PrEP among aMSM/aTGW enrolled in a daily oral PrEP cohort from two capital cities of Brazil since 2019.
Previous knowledge of LAI-PrEP remains scarce, but the high interest regarding its use has been reported. Interest in the use of LAI-PrEP is associated with eliminating the burden of daily responsibility or the risk of missing the necessary medications, lowering the costs of this method, increasing confidentiality, and decreasing the frequency of visiting PrEP clinics. The reported barriers to uptake included fear of injection, doubts on its effectiveness, side effects, and greater dependence on a health provider.
There is an urgent need to strengthen the preventive strategies against HIV infection among the youth, enhance their knowledge and those of healthcare providers, and offer safe and new options.
青少年男同性恋者（aMSM）和跨性别女性（aTGW）受人类免疫缺陷病毒（HIV）感染的影响不成比例。尽管新的暴露前预防（PrEP）方法，如长效注射（LAI-PrEP），已被美国食品和药物管理局批准，但它们在 aMSM/aTGW 中的可接受性尚不清楚。
自 2019 年以来，在巴西两个首府的每日口服 PrEP 队列中招募了 48 名 aMSM/aTGW 参与者，进行了 48 次半结构式访谈，以评估他们对 LAI-PrEP 的了解和兴趣。
尽管之前对 LAI-PrEP 的了解仍然很少，但据报道，人们对其使用的兴趣很高。对使用 LAI-PrEP 的兴趣与消除日常责任的负担或错过必要药物的风险、降低这种方法的成本、提高保密性和减少 PrEP 诊所的访问频率有关。报告的采用障碍包括对注射的恐惧、对其有效性、副作用的怀疑，以及对医疗保健提供者的更大依赖。
迫切需要加强针对青年人群的 HIV 感染预防策略，增强他们和医疗保健提供者的知识，并提供安全和新的选择。
