C-X-C基序趋化因子受体4在散发性恶性外周神经鞘瘤患者中的预后价值
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.
作者信息
Zhang Chao, Chang Fang-Yuan, Zhou Wen-Ya, Yang Ji-Long
机构信息
Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 30060, P. R. China.
National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, P. R. China.
出版信息
Chin J Cancer. 2017 Oct 11;36(1):80. doi: 10.1186/s40880-017-0246-z.
BACKGROUND
Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor (MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values.
METHODS
CXCR4, CXCL12, and Cyclin D1 protein expression in samples from 58 Chinese patients with sporadic MPNST was assessed with immunohistochemical staining. Their prognostic values were evaluated with Kaplan-Meier analysis and a log-rank test. Multivariate Cox regression analysis was used to identify independent prognostic factors.
RESULTS
High expression of CXCR4, CXCL12, and Cyclin D1 was observed in 19 (32.8%), 32 (55.2%), and 16 (27.6%) samples, respectively. CXCR4 expression was positively correlated with CXCL12 expression (r = 0.334, P = 0.010) and Cyclin D1 expression (r = 0.309, P = 0.018). Patients with high CXCR4 expression showed longer overall survival than those with low CXCR4 expression (χ = 4.642, P = 0.031).
CONCLUSION
High CXCR4 expression may define a specific subtype of sporadic MPNST with favorable prognosis.
背景
近期研究表明，C-X-C基序趋化因子受体4（CXCR4）及其配体C-X-C基序趋化因子配体12（CXCL12）可刺激1型神经纤维瘤病相关恶性外周神经鞘膜瘤（MPNST）细胞中细胞周期调节蛋白细胞周期蛋白D1的表达并促进其增殖。在本研究中，我们检测了中国患者散发性MPNST组织中CXCR4、CXCL12和细胞周期蛋白D1蛋白的表达，并探讨了它们的预后价值。
方法
采用免疫组织化学染色评估58例中国散发性MPNST患者样本中CXCR4、CXCL12和细胞周期蛋白D1蛋白的表达。采用Kaplan-Meier分析和对数秩检验评估它们的预后价值。采用多因素Cox回归分析确定独立预后因素。
结果
分别在19例（32.8%）、32例（55.2%）和16例（27.6%）样本中观察到CXCR4、CXCL12和细胞周期蛋白D1的高表达。CXCR4表达与CXCL12表达呈正相关（r = 0.334，P = 0.010），与细胞周期蛋白D1表达呈正相关（r = 0.309，P = 0.018）。CXCR4高表达患者的总生存期长于CXCR4低表达患者（χ = 4.642，P = 0.031）。
结论
CXCR4高表达可能定义了一种具有良好预后的散发性MPNST特定亚型。
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