Department of Paediatrics and Child Health, Centenary Hospital for Women and Children, Canberra, Australian Capital Territory, Australia.
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Arch Dis Child. 2018 Apr;103(4):346-351. doi: 10.1136/archdischild-2017-312982. Epub 2017 Oct 11.
To describe the point prevalence of respiratory viruses/atypical bacteria using PCR and evaluate the impact of respiratory viruses/atypical bacteria and atopy on acute severity and clinical recovery in children with hospitalised and non-hospitalised asthma exacerbations.
This was a prospective study performed during 2009-2011.
The study was performed in the emergency departments of two hospitals.
244 children aged 2-16 years presenting with acute asthma to the emergency departments were recruited. A nasopharyngeal aspirate and allergen skin prick test were performed.
The outcomes were divided into (1) acute severity outcomes (Australian National Asthma Council assessment, hospitalisation, Functional Severity Scale, Acute Asthma Score, asthma quality of life questionnaires for parents (PACQLQ) on presentation, asthma diary scores (ADS) on presentation and length of hospitalisation) and (2) recovery outcomes (PACQLQ for 21 days, ADS for 14 days and representation for asthma for 21 days).
PCR for viruses/atypical bacteria was positive in 81.7% of children (75.1% human rhinovirus, codetection in 14.2%). and were rarely detected. The presence of micro-organisms had little impact on acute asthma or recovery outcomes. Children with atopy were significantly more likely to relapse and represent for medical care by day 14 (OR 1.11, 95% CI 1.00 to 1.23).
The presence of any viruses is associated with asthma exacerbations but does not appear to influence asthma recovery. In contrast, atopy is associated with asthma relapse. and are rare triggers of acute asthma in young children.
使用 PCR 方法描述呼吸道病毒/非典型细菌的时点流行率，并评估呼吸道病毒/非典型细菌和特应性对住院和非住院哮喘加重患儿急性严重程度和临床转归的影响。
这是一项在 2009-2011 年进行的前瞻性研究。
研究在两家医院的急诊科进行。
招募了 244 名 2-16 岁因急性哮喘就诊于急诊科的儿童。进行鼻咽抽吸物和过敏原皮肤点刺试验。
结果分为（1）急性严重程度结局（澳大利亚国家哮喘理事会评估、住院、功能严重程度量表、急性哮喘评分、就诊时父母哮喘生活质量问卷（PACQLQ）、就诊时哮喘日记评分（ADS）和住院时间）和（2）恢复结局（21 天 PACQLQ、14 天 ADS 和 21 天哮喘表现）。
病毒/非典型细菌的 PCR 检测阳性率为 81.7%（75.1%为人鼻病毒，14.2%为合并感染），很少检测到 和 。微生物的存在对急性哮喘或恢复结局的影响很小。特应性患儿在第 14 天复发和再次接受医疗的可能性明显更高（OR 1.11，95%CI 1.00 至 1.23）。
任何病毒的存在均与哮喘加重相关，但似乎不会影响哮喘恢复。相比之下，特应性与哮喘复发相关。 和 是幼儿急性哮喘的罕见触发因素。
