Nakae Yoshiki, Hyuga Mizuki, Terada Yuta, Kishimoto Wataru, Fukunaga Akiko, Tabata Sumie, Maesako Yoshitomo, Komatsu Kenichi, Higuchi Osamu, Nakane Toshinari, Arima Nobuyoshi
Department of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Department of Neurology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Intern Med. 2017 Dec 15;56(24):3347-3351. doi: 10.2169/internalmedicine.9096-17. Epub 2017 Oct 11.
Autoimmune autonomic ganglionopathy is an autonomic disorder that occurs as a symptom of paraneoplastic neurological syndrome. To date, there have been no reports on multiple myeloma with autoimmune autonomic ganglionopathy. A 37-year-old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma (IgG kappa type), and a serological examination revealed the presence of anti-ganglionic nicotinic acetylcholine receptor (anti-gAChR) antibodies. She was treated for multiple myeloma, as a result, the autonomic disturbance improved and her anti-gAChR antibody titer decreased to undetectable levels, despite the fact that she only achieved a partial remission of multiple myeloma. Treatment for multiple myeloma may improve autoimmune autonomic ganglionopathy.
自身免疫性自主神经节病是一种作为副肿瘤性神经综合征症状出现的自主神经障碍。迄今为止，尚无关于伴有自身免疫性自主神经节病的多发性骨髓瘤的报道。一名37岁的日本女性因体位性低血压被诊断为多发性骨髓瘤（IgG κ型），血清学检查显示存在抗神经节烟碱型乙酰胆碱受体（抗gAChR）抗体。她接受了多发性骨髓瘤治疗，结果，尽管她的多发性骨髓瘤仅达到部分缓解，但自主神经功能障碍得到改善，抗gAChR抗体滴度降至无法检测的水平。多发性骨髓瘤的治疗可能会改善自身免疫性自主神经节病。
