• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

内镜下黏膜下剥离术治疗伴有多发幽门螺杆菌阴性早期胃癌的家族性腺瘤性息肉病

Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection.

作者信息

Yaguchi Katsuki, Makazu Makomo, Hirasawa Kingo, Sugimori Makoto, Kobayashi Ryosuke, Sato Chiko, Ikeda Ryosuke, Fukuchi Takehide, Ishii Yasuaki, Kaneko Hiroaki, Shibata Wataru, Yamanaka Shoji, Inayama Yoshiaki, Maeda Shin

机构信息

Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Japan.

Yokohama City University School of Medicine, Japan.

出版信息

Intern Med. 2017 Dec 15;56(24):3283-3286. doi: 10.2169/internalmedicine.8735-16. Epub 2017 Oct 11.

DOI:10.2169/internalmedicine.8735-16
PMID:29021452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5790714/
Abstract

Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type. Periodical endoscopic surveillance is important for the detection of cancers at an early stage.

摘要

家族性腺瘤性息肉病（FAP）患者很少发生胃癌，幽门螺杆菌感染可能会增加FAP相关胃癌的风险。我们报告了一例64岁女性患者，她在未感染幽门螺杆菌的情况下发生了多发同步早期胃癌。通过内镜下黏膜下剥离术成功治疗了9个癌灶。免疫组化分析显示，肿瘤对黏蛋白（MUC）2、MUC6和CDX2呈阳性，但对MUC5AC呈阴性，提示肿瘤为胃肠混合型。定期内镜监测对于早期癌症的检测很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5611/5790714/f67eac4870d2/1349-7235-56-3283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5611/5790714/14c94220ffa2/1349-7235-56-3283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5611/5790714/f67eac4870d2/1349-7235-56-3283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5611/5790714/14c94220ffa2/1349-7235-56-3283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5611/5790714/f67eac4870d2/1349-7235-56-3283-g002.jpg

相似文献

1
Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection.内镜下黏膜下剥离术治疗伴有多发幽门螺杆菌阴性早期胃癌的家族性腺瘤性息肉病
Intern Med. 2017 Dec 15;56(24):3283-3286. doi: 10.2169/internalmedicine.8735-16. Epub 2017 Oct 11.
2
Intestinal-type gastric adenocarcinoma without Helicobacter pylori infection successfully treated with endoscopic submucosal dissection.内镜下黏膜下剥离术成功治疗无幽门螺杆菌感染的肠型胃腺癌
Clin J Gastroenterol. 2016 Aug;9(4):228-32. doi: 10.1007/s12328-016-0654-7. Epub 2016 Jun 3.
3
Clinicopathological features of early gastric cancers arising in uninfected patients.未感染者中发生的早期胃癌的临床病理特征。
World J Gastroenterol. 2020 May 28;26(20):2618-2631. doi: 10.3748/wjg.v26.i20.2618.
4
Underwater endoscopic mucosal resection for a residual gastric lesion after unsuccessful endoscopic submucosal dissection in a patient with familial adenomatous polyposis.一名家族性腺瘤性息肉病患者在内镜黏膜下剥离术失败后，对残留胃病变进行水下内镜黏膜切除术。
Dig Endosc. 2024 Feb;36(2):248-249. doi: 10.1111/den.14723. Epub 2023 Dec 11.
5
Comparison of dysplastic fundic gland polyps in patients with and without familial adenomatous polyposis.比较有家族性腺瘤性息肉病和无家族性腺瘤性息肉病患者的胃底腺息肉异型性。
Histopathology. 2018 Jun;72(7):1172-1179. doi: 10.1111/his.13485. Epub 2018 Mar 24.
6
Endoscopic submucosal dissection for multiple gastric superficial adenocarcinomas identified in patient with familial adenomatous polyposis.
Dig Endosc. 2020 May;32(4):e57-e58. doi: 10.1111/den.13607. Epub 2020 Feb 11.
7
Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis.一名患轻度家族性腺瘤性息肉病患者胃腺癌及发育异常病变中大肠腺瘤-癌序列的基因改变
Mol Genet Genomic Med. 2020 Sep;8(9):e1348. doi: 10.1002/mgg3.1348. Epub 2020 Jun 16.
8
Feasibility of underwater endoscopic mucosal resection for endoscopic management of gastric neoplasms in patients with familial adenomatous polyposis.经肛门内镜微创手术治疗家族性腺瘤性息肉病患者胃肿瘤的可行性。
Surg Endosc. 2023 Sep;37(9):6877-6884. doi: 10.1007/s00464-023-10175-x. Epub 2023 Jun 13.
9
Dysplastic changes in gastric fundic gland polyps of patients with familial adenomatous polyposis.家族性腺瘤性息肉病患者胃底腺息肉的发育异常改变
Ital J Gastroenterol Hepatol. 1999 Apr;31(3):192-7.
10
Phenotypic variations of gastric neoplasms in familial adenomatous polyposis are associated with endoscopic status of atrophic gastritis.家族性腺瘤性息肉病中胃肿瘤的表型变化与萎缩性胃炎的内镜状态相关。
Dig Endosc. 2020 May;32(4):547-556. doi: 10.1111/den.13512. Epub 2019 Oct 31.

引用本文的文献

1
Two Cases, Too Little, Too Late: Surveillance for Gastric Cancer in Patients with FAP.两例病例，太少，太迟：家族性腺瘤性息肉病患者的胃癌监测
Dig Dis Sci. 2023 Nov;68(11):4117-4122. doi: 10.1007/s10620-023-08097-8. Epub 2023 Sep 15.
2
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the Clinical Practice of Hereditary Colorectal Cancer.日本结直肠癌学会（JSCCR）2020年遗传性结直肠癌临床实践指南。
Int J Clin Oncol. 2021 Aug;26(8):1353-1419. doi: 10.1007/s10147-021-01881-4. Epub 2021 Jun 29.
3
Genetic alteration of colorectal adenoma-carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis.

本文引用的文献

1
Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients.日本家族性腺瘤性息肉病患者的上消化道肿瘤
Jpn J Clin Oncol. 2016 Apr;46(4):310-5. doi: 10.1093/jjco/hyv210. Epub 2016 Jan 26.
2
Familial adenomatous polyposis-associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features.家族性腺瘤性息肉病相关的和散发性的上消化道幽门腺腺瘤具有共同的遗传特征。
Histopathology. 2015 Nov;67(5):689-98. doi: 10.1111/his.12705. Epub 2015 May 14.
3
The endoscopic diagnosis of early gastric cancer.
一名患轻度家族性腺瘤性息肉病患者胃腺癌及发育异常病变中大肠腺瘤-癌序列的基因改变
Mol Genet Genomic Med. 2020 Sep;8(9):e1348. doi: 10.1002/mgg3.1348. Epub 2020 Jun 16.
早期胃癌的内镜诊断
Ann Gastroenterol. 2013;26(1):11-22.
4
Upper GI tract lesions in familial adenomatous polyposis (FAP): enrichment of pyloric gland adenomas and other gastric and duodenal neoplasms.家族性腺瘤性息肉病（FAP）中的上消化道病变：幽门腺腺瘤和其他胃和十二指肠肿瘤的富集。
Am J Surg Pathol. 2014 Mar;38(3):389-93. doi: 10.1097/PAS.0000000000000146.
5
Characteristics and prognosis of synchronous multiple early gastric cancer.同步多发早期胃癌的特征与预后。
World J Gastroenterol. 2013 Nov 7;19(41):7154-9. doi: 10.3748/wjg.v19.i41.7154.
6
Clinical characteristics of gastric cancer in patients with familial adenomatous polyposis.家族性腺瘤性息肉病患者胃癌的临床特征。
Tohoku J Exp Med. 2013 Feb;229(2):143-6. doi: 10.1620/tjem.229.143.
7
Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.幽门腺腺瘤：一种与胃小凹型腺瘤不同的实体。
Am J Surg Pathol. 2009 Feb;33(2):186-93. doi: 10.1097/PAS.0b013e31817d7ff4.
8
Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome.一名患有家族性腺瘤性息肉病综合征的患者，胃底腺息肉引发胃腺癌。
Am Surg. 2008 Jan;74(1):79-83.
9
Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.家族性腺瘤性息肉病（FAP）患者结肠肿瘤与结肠外肿瘤之间APC突变特征的差异：随表型的变化
Int J Cancer. 2008 Jun 1;122(11):2491-7. doi: 10.1002/ijc.23390.
10
Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice.Cdx2转基因小鼠中肠化生发展为胃癌
Cancer Res. 2004 Nov 1;64(21):7740-7. doi: 10.1158/0008-5472.CAN-04-1617.