内镜下黏膜下剥离术治疗伴有多发幽门螺杆菌阴性早期胃癌的家族性腺瘤性息肉病
Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection.
作者信息
Yaguchi Katsuki, Makazu Makomo, Hirasawa Kingo, Sugimori Makoto, Kobayashi Ryosuke, Sato Chiko, Ikeda Ryosuke, Fukuchi Takehide, Ishii Yasuaki, Kaneko Hiroaki, Shibata Wataru, Yamanaka Shoji, Inayama Yoshiaki, Maeda Shin
机构信息
Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Japan.
Yokohama City University School of Medicine, Japan.
出版信息
Intern Med. 2017 Dec 15;56(24):3283-3286. doi: 10.2169/internalmedicine.8735-16. Epub 2017 Oct 11.
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type. Periodical endoscopic surveillance is important for the detection of cancers at an early stage.
家族性腺瘤性息肉病（FAP）患者很少发生胃癌，幽门螺杆菌感染可能会增加FAP相关胃癌的风险。我们报告了一例64岁女性患者，她在未感染幽门螺杆菌的情况下发生了多发同步早期胃癌。通过内镜下黏膜下剥离术成功治疗了9个癌灶。免疫组化分析显示，肿瘤对黏蛋白（MUC）2、MUC6和CDX2呈阳性，但对MUC5AC呈阴性，提示肿瘤为胃肠混合型。定期内镜监测对于早期癌症的检测很重要。
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