Garrean Sean, Hering Justin, Saied Abdul, Jani Jigna, Espat N Joseph
Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, USA.
Am Surg. 2008 Jan;74(1):79-83.
Familial adenomatous polyposis (FAP) is a rare hereditary syndrome characterized by multiple colorectal polyps and early development of colorectal cancer. Although FAP uniformly involves the large bowel, it may also produce lesions in the stomach and upper intestinal tract. Fundic gland polyps are the most common gastric lesion in FAP. In the general population, these polyps are considered benign and have no malignant potential. However, in FAP patients, fundic gland polyps have been occasionally recognized as precursor lesions from which invasive cancer may develop. Herein, we present a case of gastric adenocarcinoma arising from fundic gland polyps in an FAP patient. We also review reported cases of gastric cancer in FAP and FAP variant patients in an effort to better understand the pathology, clinical course, and optimal screening and treatment strategies for this disease manifestation.
家族性腺瘤性息肉病（FAP）是一种罕见的遗传性综合征，其特征为多发性结肠息肉和结直肠癌的早期发生。虽然FAP通常累及大肠，但也可能在胃和上消化道产生病变。胃底腺息肉是FAP中最常见的胃部病变。在普通人群中，这些息肉被认为是良性的，没有恶变潜能。然而，在FAP患者中，胃底腺息肉偶尔被认为是可能发展为浸润性癌的前驱病变。在此，我们报告一例FAP患者胃底腺息肉发生胃腺癌的病例。我们还回顾了FAP和FAP变异型患者中报道的胃癌病例，以更好地了解这种疾病表现的病理学、临床过程以及最佳筛查和治疗策略。
