Arora Rajat, Abrol Nitin, Antonisamy B, Vanitha S, Chandrasingh J, Kumar Santosh, Kekre Nitin, Devasia Antony
Department of Urology, Christian Medical College, Vellore, Tamil Nadu, India.
Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
Indian J Urol. 2017 Oct-Dec;33(4):291-293. doi: 10.4103/iju.IJU_340_16.
Fetuin-A is a glycoprotein secreted by liver and has been shown to inhibit extraosseous mineralization. Urolithiasis may be a manifestation in the urinary tract due to fetuin deficiency in urine. The objective of this study was to compare the 24-h urine and serum fetuin-A levels of patients with and without urolithiasis.
Serum and 24-h urine fetuin-A levels were measured in 41 patients with bilateral, multiple, or recurrent urinary tract calculi (Group A) and 41 matched controls with no calculi (Group B). Fetuin levels were measured by enzyme linked immunosorbent assay. Serum and urine fetuin-A levels in the two groups were compared.
The median (range) 24-h urine fetuin-A value in Group A was 11.9 (1.12-221) mg/day and in Group B was 37.7 (1.28-125) mg/day. This difference was statistically significant (Mann-Whitney test, = 0.0169). The median (range) serum fetuin-A in Group A was 0.67 (0.05-2.68) g/L and in Group B was 0.99 (0.01-5.5) g/L. The difference between serum values in the two arms was not statistically significant (Mann-Whitney test, = 0.1817). However, the serum creatinine-adjusted mean log serum fetuin and urine fetuin were significantly different in the two arms ( = 0.003). The mean ± standard deviation (range) serum creatinine in Group A was 0.98 ± 0.25 (0.56-1.58) mg% and in Group B was 0.83 ± 0.16 (0.58-1.18) mg% (two sample -test, = 0.0031).
Patients with urolithiasis have lower urine fetuin-A and creatinine-adjusted serum fetuin-A levels.
胎球蛋白-A是肝脏分泌的一种糖蛋白，已被证明可抑制骨外矿化。尿石症可能是由于尿液中胎球蛋白缺乏而在尿路出现的一种表现。本研究的目的是比较有和没有尿石症患者的24小时尿和血清胎球蛋白-A水平。
对41例双侧、多发或复发性尿路结石患者（A组）和41例无结石的匹配对照者（B组）测定血清和24小时尿胎球蛋白-A水平。通过酶联免疫吸附测定法测量胎球蛋白水平。比较两组的血清和尿胎球蛋白-A水平。
A组24小时尿胎球蛋白-A值的中位数（范围）为11.9（1.12 - 221）mg/天，B组为37.7（1.28 - 125）mg/天。这种差异具有统计学意义（曼-惠特尼检验，P = 0.0169）。A组血清胎球蛋白-A的中位数（范围）为0.67（0.05 - 2.68）g/L，B组为0.99（0.01 - 5.5）g/L。两组血清值之间的差异无统计学意义（曼-惠特尼检验，P = 0.1817）。然而，两组经血清肌酐校正的平均对数血清胎球蛋白和尿胎球蛋白有显著差异（P = 0.003）。A组血清肌酐的平均值±标准差（范围）为0.98±0.25（0.56 - 1.58）mg%，B组为0.83±0.16（0.58 - 1.18）mg%（两样本t检验，P = 0.0031）。
尿石症患者的尿胎球蛋白-A和经肌酐校正的血清胎球蛋白-A水平较低。
