Lal M, Schöneich C, Mönig J, Asmus K D
Hahn-Meitner-Institut Berlin, Bereich Strahlenchemie, F.R.G.
Int J Radiat Biol. 1988 Nov;54(5):773-85. doi: 10.1080/09553008814552211.
Absolute rate constants have been measured by means of pulse radiolysis for the reactions of various halogenated aliphatic compounds (ethane derivatives, including the anaesthetics halothane, enflurane, isoflurane and methoxyflurane) with hydrated electrons and .OH radicals, the reactions of halogenated carbon-centered radicals, derived thereby, with molecular oxygen, and the reactions of halogenated peroxyl radicals with various antioxidants (ascorbate, chlorpromazine, promethazine, propyl gallate, ABTS) in aqueous solutions. All oxygen addition reactions occur essentially diffusion-controlled. This finding is correlated with the stereoelectronic properties of the primary carbon-centred radicals. The oxidative power of the halogenated peroxyl radicals reflects the inductive -I effect of the halogens and accordingly increases with the degree of halogen substitution, with fluorine substituents being particularly effective. The peroxyl radicals derived from freon 113, namely CClF2CClFOO. and CCl2FCF2OO., have been identified as the best oxidants among these species.
通过脉冲辐解测量了各种卤代脂肪族化合物（乙烷衍生物，包括麻醉剂氟烷、恩氟烷、异氟烷和甲氧氟烷）与水合电子和·OH自由基反应的绝对速率常数，由此衍生的卤代碳中心自由基与分子氧的反应，以及卤代过氧自由基与水溶液中各种抗氧化剂（抗坏血酸盐、氯丙嗪、异丙嗪、没食子酸丙酯、ABTS）的反应。所有氧加成反应基本上都是扩散控制的。这一发现与初级碳中心自由基的立体电子性质相关。卤代过氧自由基的氧化能力反映了卤素的诱导-I效应，因此随着卤素取代程度的增加而增强，氟取代基尤为有效。已确定氟利昂113衍生的过氧自由基，即CClF2CClFOO·和CCl2FCF2OO·，是这些物种中最好的氧化剂。
