Chae Kwon-Seok, Kim Yong-Hwan
Department of Biology Education, Kyungpook National University, Daegu, South Korea.
Department of Nanoscience & Nanotechnology, Kyungpook National University, Daegu, South Korea.
Front Hum Neurosci. 2017 Sep 27;11:478. doi: 10.3389/fnhum.2017.00478. eCollection 2017.
Throughout the long history of various therapeutic trials of transcranial magnetic stimulation (TMS), some TMS protocols have been reported to be clearly effective in the treatment of neurodegenerative diseases. Despite promising results from repetitive TMS (rTMS) using low frequency electromagnetic fields (EMFs) for neurodegenerative diseases, the low reproducibility has hampered the clinical applications of rTMS. Here, based on the notion of radical pair mechanism explaining magnetoreception in living organisms, we propose a new perspective that rTMS with controlled geomagnetic field (rTMS-GMF) can be an efficient and reproducible therapeutic approach for neurodegenerative diseases. In addition, combined consideration of imprinted GMF and/or EMFs in patients' earlier life may augment the potential efficacy of the rTMS-GMF. The investigation of this approach is intriguing and may have a high impact on the technical suitability and clinical application of the rTMS-GMF in the near future.
在经颅磁刺激（TMS）各种治疗试验的漫长历史中，有报道称一些TMS方案在治疗神经退行性疾病方面明显有效。尽管使用低频电磁场（EMF）的重复经颅磁刺激（rTMS）在神经退行性疾病治疗中取得了令人鼓舞的结果，但低重现性阻碍了rTMS的临床应用。在此，基于自由基对机制解释生物体磁感受的概念，我们提出一个新观点，即具有可控地磁场的rTMS（rTMS-GMF）可以成为治疗神经退行性疾病的一种有效且可重复的治疗方法。此外，综合考虑患者早年生活中印记的地磁场和/或电磁场可能会增强rTMS-GMF的潜在疗效。对这种方法的研究很有趣，并且可能在不久的将来对rTMS-GMF的技术适用性和临床应用产生重大影响。
