胰管结扎兔十二指肠黏膜中生长抑素水平及结合情况
Somatostatin levels and binding in duodenal mucosa of rabbits with ligation of the pancreatic duct.
作者信息
Guijarro L G, Arilla E
机构信息
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcalà de Henares, Madrid, Spain.
出版信息
J Endocrinol. 1988 Aug;118(2):227-32. doi: 10.1677/joe.0.1180227.
Atrophy of the exocrine pancreas was induced in rabbits by pancreatic duct ligation. Somatostatin concentration and binding in cytosol from rabbit duodenal mucosa were studied after 6 and 14 weeks of pancreatic duct ligation. Somatostatin-like immunoreactivity was significantly increased in the duodenal mucosa in both periods. Scatchard analysis showed a parallel increase in the number of binding sites rather than a change in their affinity. The physiological significance of these findings remains to be clarified.
通过结扎胰管在兔中诱导外分泌胰腺萎缩。在结扎胰管6周和14周后，研究了兔十二指肠黏膜细胞质中生长抑素的浓度和结合情况。在这两个时期，十二指肠黏膜中生长抑素样免疫反应性均显著增加。Scatchard分析显示结合位点数量平行增加，而非其亲和力发生变化。这些发现的生理意义仍有待阐明。
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