Gozes Illana
The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel.
EPMA J. 2017 Sep 4;8(3):255-259. doi: 10.1007/s13167-017-0110-x. eCollection 2017 Sep.
This short review looks at Alzheimer's disease (AD) diagnosis through my own point of view, going from imaging through cerebrospinal fluid to blood proteins. Over the last couple of years, we have published two papers targeted at Alzheimer's diagnosis. In one paper, we took an approach of selecting a specific target, namely, activity-dependent neuroprotective protein (ADNP), and our results tightened the association of ADNP blood expression with intelligence. In another paper, we took an unbiased approach of analysis of all genes expressed in lymphoblastoid cells lines and discovered changes in expression of the regulator of G-protein signaling 2 (RGS2) as a potential AD predictor. This review will assess our data in comparison to selected independent studies focusing on blood protein biomarkers as well as assessing saliva and urine samples with potential predictive value for AD. Furthermore, the review will provide directions for a combination of innovative markers, stratifying the population toward disease prevention and personalized medicine.
这篇简短的综述从我的视角审视了阿尔茨海默病（AD）的诊断，涵盖了从影像学检查到脑脊液分析再到血液蛋白检测的各个方面。在过去几年里，我们发表了两篇针对阿尔茨海默病诊断的论文。在其中一篇论文中，我们采用了选择特定靶点的方法，即活性依赖的神经保护蛋白（ADNP），我们的研究结果进一步强化了ADNP血液表达与智力之间的关联。在另一篇论文中，我们采用了对淋巴母细胞系中所有表达基因进行无偏分析的方法，并发现G蛋白信号调节因子2（RGS2）的表达变化可作为AD的潜在预测指标。本综述将把我们的数据与其他一些专注于血液蛋白生物标志物的独立研究进行比较，同时评估唾液和尿液样本对AD的潜在预测价值。此外，本综述还将为创新标志物的组合提供指导方向，以便对人群进行分层，实现疾病预防和个性化医疗。
