Lindberg S, Fjälling M, Jacobsson L, Jansson S, Tisell L E
Department of Diagnostic Radiology, University of Göteborg, Sweden.
J Nucl Med. 1988 Oct;29(10):1638-43.
Iodine-131 MIBG scans were performed in 59 patients in order to localize intra- or extra-adrenal pheochromocytomas (pheos), or to visualize hyperplastic adrenal medulla. Images were obtained from the pelvis to the base of the skull on Days 1, 4, and 7 after tracer injection. The 15 patients with histopathologic confirmation of adrenal medullary disease had positive scans. In three of these, the pheos were visible only on images obtained on Day 7. One scan was false negative. After excluding patients with a predisposition to adrenal medullary disease, nine subjects (28%) without verification of pheo displayed adrenal uptake of the radionuclide. Late images produce a low rate of false-negative scans; the background activity diminishes and even small pheos can be detected. In order to increase the quality of late images, 40 MBq [131I]MIBG was used instead of 20 MBq. The dosimetric considerations are discussed.
对59例患者进行了碘-131间碘苄胍（MIBG）扫描，以定位肾上腺内或肾上腺外嗜铬细胞瘤（嗜铬细胞瘤），或观察肾上腺髓质增生情况。在注射示踪剂后的第1天、第4天和第7天，从骨盆至颅底获取图像。15例经组织病理学证实患有肾上腺髓质疾病的患者扫描结果为阳性。其中3例，嗜铬细胞瘤仅在第7天获得的图像上可见。1次扫描为假阴性。排除有肾上腺髓质疾病倾向的患者后，9名未经验证为嗜铬细胞瘤的受试者（28%）显示肾上腺摄取放射性核素。延迟图像产生假阴性扫描的比率较低；背景活性降低，甚至小的嗜铬细胞瘤也能被检测到。为了提高延迟图像的质量，使用了40MBq的[131I]MIBG代替20MBq。讨论了剂量学方面的考虑因素。
