Pablo Luis Emilio, Bambo Maria Pilar, Cameo Beatriz, Ferrández Blanca, Güerri Noemí, Polo Vicente, Larrosa Jose Manuel, Moreno-Montañés Javier, Garcia-Martin Elena
Ophthalmology Department, Miguel Servet University Hospital, C/Padre Arrupe, Consultas Externas de Oftalmología, 50009, Saragossa, Spain.
Aragon Institute for Health Research (IIS Aragón), University of Zaragoza, Saragossa, Spain.
Jpn J Ophthalmol. 2018 Jan;62(1):41-47. doi: 10.1007/s10384-017-0538-5. Epub 2017 Oct 11.
To evaluate automatic peripapillary choroidal thickness (PPCT) measurements in a wide area around the optic disc and various established zones in primary open-angle glaucoma (POAG) patients and age- and sex-matched healthy controls using a new swept-source optical coherence tomography (SS-OCT) device.
Single center cross-sectional observational study.
A total of 135 POAG patients and 86 healthy subjects were consecutively enrolled. An optic disc 6.0 × 6.0 mm three-dimensional scan OD was obtained using the SS-OCT Triton. A 26 × 26 cube-grid centered in the optic disc was generated to automatically measure choroidal thickness. Seven choroidal zones were established (superior temporal, central, and nasal; inferior temporal, central, and nasal, and the optic nerve head) and compared between healthy controls and POAG patients.
PPCT was significantly thinner in the central superior, nasal superior, and nasal inferior zones of the POAG subjects. Choroidal thickness in the central superior zone was 124.61 ± 54.95 µm in POAG group vs 156.17 ± 80.89 µm in healthy controls (p = 0.029); in the nasal superior zone, 133.84 ± 58.89 µm in the POAG group vs 168.34 ± 73.45 µm in healthy controls (p = 0.012); and in the nasal inferior zone, 113.45 ± 49.93 µm in the POAG group vs 137.47 ± 65.96 µm in healthy controls (p = 0.049).
Compared with healthy subjects, glaucoma patients present with peripapillary choroidal thinning, especially in the central superior, nasal superior, and nasal inferior zones. The new SS-OCT could be a useful tool to evaluate choroidal thinning, and it could be an additional support to facilitate glaucoma diagnosis.
使用一种新型扫频光学相干断层扫描（SS-OCT）设备，评估原发性开角型青光眼（POAG）患者及年龄和性别匹配的健康对照者视盘周围大面积区域以及各个既定区域的自动视盘周围脉络膜厚度（PPCT）测量值。
单中心横断面观察性研究。
连续纳入135例POAG患者和86例健康受试者。使用SS-OCT Triton对视盘进行6.0×6.0mm的三维扫描。以视盘为中心生成一个26×26的立方格网，以自动测量脉络膜厚度。建立了七个脉络膜区域（颞上、中央和鼻侧；颞下、中央和鼻侧，以及视神经乳头），并在健康对照者和POAG患者之间进行比较。
POAG受试者的中央上方、鼻上方和鼻下方区域的PPCT明显更薄。POAG组中央上方区域的脉络膜厚度为124.61±54.95μm，而健康对照组为156.17±80.89μm（p = 0.029）；在鼻上方区域，POAG组为133.84±58.89μm，健康对照组为168.34±73.45μm（p = 0.012）；在鼻下方区域，POAG组为113.45±49.93μm，健康对照组为137.47±65.96μm（p = 0.049）。
与健康受试者相比，青光眼患者存在视盘周围脉络膜变薄，尤其是在中央上方、鼻上方和鼻下方区域。新型SS-OCT可能是评估脉络膜变薄的有用工具，并且可能为青光眼诊断提供额外支持。
