Physical Exercise Can Spur Beneficial Neoangiogenesis and Microvasculature Remodeling Within the Heart - Our Salvation?

Economic and social burden of cardiovascular diseases remains enormous and even still rising. There is not enough mass evidence in scientific journals that could describe the course of the process of neoangiogenesis in relatively "healthy" heart after regular endurance exercise. Even though, in this review, we are showing preliminary evidence that this can be one of really cheap and effective preventive means. We are elucidating some of the cellular signaling pathways how exercise could affect neoangiogenesis and ameliorate performance of the heart. Key roles in this process are mechanical forces (mainly increased velocity of blood flow and shear stress) and subsequent rise of angiogenic biological factors (mainly VEGFA).