MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, State Key Laboratory of Urban Water Resource and Environment (SKLUWRE), School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin 150001, P.R. China.
CSIRO Manufacturing , Private Bag 10, Clayton South, Victoria 3169, Australia.
ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38877-38886. doi: 10.1021/acsami.7b07373. Epub 2017 Oct 26.
Membrane separation is a promising technology for extracting temperature-sensitive organic molecules from solvents. However, a lack of membrane materials that are permeable toward organic solvents yet highly selective curtails large-scale membrane applications. To overcome the trade-off between flux and selectivity, additional molecular transportation pathways are constructed in ultrathin polyamide membranes using highly hydrostable metal organic frameworks with diverse functional surface architectures. Additional passageways enhance water permeance by 84% (15.4 L m h bar) with nearly 100% rose bengal rejection and 97.6% azithromycin rejection, while showing excellent separation performance in ethyl acetate, ketones, and alcohols. These unique composite membranes remain stable in both aqueous and organic solvent environments. This immediately finds application in the purification of aqueous mixtures containing organic soluble compounds, such as antibiotics, during pharmaceutical manufacturing.
膜分离是一种很有前途的技术，可以从溶剂中提取对温度敏感的有机分子。然而，缺乏对有机溶剂具有高渗透性和高选择性的膜材料，限制了大规模膜应用。为了克服通量和选择性之间的权衡，在超薄聚酰胺膜中使用具有不同功能表面结构的高度稳定的金属有机骨架构建了额外的分子传输途径。额外的通道使水透过率提高了 84%（15.4 L m h bar），对玫瑰红的截留率接近 100%，对阿奇霉素的截留率为 97.6%，同时在乙酸乙酯、酮和醇中表现出优异的分离性能。这些独特的复合膜在水相和有机溶剂环境中都保持稳定。这立即在制药生产过程中用于从含有有机可溶性化合物（如抗生素）的水性混合物中进行纯化。
