Zenk John L, Frestedt Joy L, Kuskowski Michael A
1 Zenk Medical Consulting LLC, Minneapolis, Minnesota, USA.
2 Alimentix, the Minnesota Diet Research Center , Saint Louis Park, Minnesota, USA.
J Med Food. 2018 Feb;21(2):154-158. doi: 10.1089/jmf.2017.0023. Epub 2017 Oct 12.
A double-blind crossover pilot trial tested the hypothesis that botanically derived calcium could demonstrate greater influence over calcium metabolism markers compared with a nonplant-derived calcium carbonate supplement or placebo. Twelve fasting female subjects received a single oral dose of Aquamin F™ (derived from the marine algal Lithothamnion sp.), or calcium carbonate, or placebo. Blood and urine samples were collected at baseline and over 12 h to evaluate ionized and total calcium and parathyroid hormone (PTH). Subjects treated with Aquamin F demonstrated significantly greater urinary clearance of calcium after 12 h compared with placebo (P = .004). Following a meal at 90 min, subjects treated with Aquamin F demonstrated a more prolonged suppression of serum PTH concentration (significantly lower than placebo at 90, 120, and 240 min). Calcium carbonate provided an intermediate response; urinary clearance was not significantly different from placebo treatment and PTH was only significantly lower than placebo at 90 min. Aquamin F may demonstrate greater influence over these markers of calcium metabolism than calcium carbonate or placebo, as suggested by a greater calciuric response and a more prolonged suppression of serum PTH concentrations following a meal in premenopausal women.
与非植物来源的碳酸钙补充剂或安慰剂相比，植物来源的钙对钙代谢标志物的影响更大。12名空腹女性受试者口服单剂量的Aquamin F™（源自海藻石枝藻属）、碳酸钙或安慰剂。在基线期及12小时内采集血液和尿液样本，以评估离子钙、总钙和甲状旁腺激素（PTH）。与安慰剂相比，接受Aquamin F治疗的受试者在12小时后尿钙清除率显著更高（P = 0.004）。在90分钟进食后，接受Aquamin F治疗的受试者血清PTH浓度的抑制作用持续时间更长（在90、120和240分钟时显著低于安慰剂）。碳酸钙的反应介于两者之间；尿清除率与安慰剂治疗无显著差异，PTH仅在90分钟时显著低于安慰剂。如绝经前女性进食后更大的尿钙反应和血清PTH浓度的更长时间抑制所示，Aquamin F对这些钙代谢标志物的影响可能比碳酸钙或安慰剂更大。
