消毒副产物暴露与头面部出生缺陷的关联。
Associations Between Disinfection By-Product Exposures and Craniofacial Birth Defects.
机构信息
Association of Schools and Programs of Public Health, hosted by U.S. Environmental Protection Agency, National Center for Environmental Assessment, Office of Research and Development, Cincinnati, Ohio (Mr Kaufman); National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, Ohio (Dr Wright); Campbell University, School of Osteopathic Medicine, Lillington, North Carolina (Ms Evans); Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey (Dr Rivera-Núñez); Independent Researcher, New York, New York (Ms Meyer); and National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina (Dr Narotsky).
出版信息
J Occup Environ Med. 2018 Feb;60(2):109-119. doi: 10.1097/JOM.0000000000001191.
OBJECTIVE
The aim of this study was to examine associations between craniofacial birth defects (CFDs) and disinfection by-product (DBP) exposures, including the sum of four trihalomethanes (THM4) and five haloacetic acids (HAA5) (ie, DBP9).
METHODS
We calculated first trimester adjusted odds ratios (aORs) for different DBPs in a matched case-control study of 366 CFD cases in Massachusetts towns with complete 1999 to 2004 THM and HAA data.
RESULTS
We detected elevated aORs for cleft palate with DBP9 (highest quintile aOR = 3.52; 95% CI: 1.07, 11.60), HAA5, trichloroacetic acid (TCAA), and dichloroacetic acid. We detected elevated aORs for eye defects with TCAA and chloroform.
CONCLUSION
This is the first epidemiological study of DBPs to examine eye and ear defects, as well as HAAs and CFDs. The associations for cleft palate and eye defects highlight the importance of examining specific defects and DBPs beyond THM4.
目的
本研究旨在探讨颅面出生缺陷（CFD）与消毒副产物（DBP）暴露之间的关联，包括四种三卤甲烷（THM4）和五种卤乙酸（HAA5）的总和（即 DBP9）。
方法
我们在马萨诸塞州的一个匹配病例对照研究中，对 366 例 CFD 病例进行了分析，这些病例在 1999 年至 2004 年期间有完整的 THM 和 HAA 数据，计算了不同 DBP 的第一孕期调整比值比（aOR）。
结果
我们发现 DBP9（最高五分位数 aOR=3.52；95%CI：1.07，11.60）、HAA5、三氯乙酸（TCAA）和二氯乙酸与腭裂的 aOR 升高有关。我们还发现 TCAA 和氯仿与眼部缺陷的 aOR 升高有关。
结论
这是首次对 DBPs 进行的眼部和耳部缺陷以及 HAAs 和 CFDs 的流行病学研究。腭裂和眼部缺陷的相关性突出了检查特定缺陷和 DBP9 以外的 THM4 的重要性。
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