Reuss A, Wladimiroff J W, Stewart P A, Scholtmeijer R J
Department of Obstetrics and Gynaecology, Academic Hospital Rotterdam-Dijkzigt, Erasmus University, The Netherlands.
Lancet. 1988 Oct 22;2(8617):949-51. doi: 10.1016/s0140-6736(88)92609-8.
Fetal outcome was studied in 43 consecutive cases of fetal obstructive uropathy in which no prenatal treatment was undertaken: 12 babies survived. In the 31 who did not survive, oligohydramnios was present in 24 and urethral atresia was the most common cause of obstruction (in 27). At necropsy, bilateral renal dysplasia was found in 23 and pulmonary hypoplasia in 13; 16 had structural or chromosomal anomalies, less than half of which were detected by prenatal ultrasound. In the survivors, 8 had posterior urethral valves, 1 had oligohydramnios, and 2 had associated anomalies. Obstructive uropathy is often associated with other anomalies which may escape prenatal ultrasound detection, and studies to determine the efficacy of intrauterine decompression techniques must allow for this observation.
对43例未接受产前治疗的连续性胎儿梗阻性肾病病例的胎儿结局进行了研究：12例婴儿存活。在未存活的31例中，24例存在羊水过少，尿道闭锁是最常见的梗阻原因（27例）。尸检时，23例发现双侧肾发育不全，13例发现肺发育不全；16例有结构或染色体异常，其中不到一半在产前超声检查中被发现。在存活者中，8例有后尿道瓣膜，1例有羊水过少，2例有相关异常。梗阻性肾病常与其他可能未被产前超声检测到的异常相关，确定宫内减压技术疗效的研究必须考虑到这一观察结果。
