MacKay Douglas
Bioethics. 2018 Jan;32(1):59-67. doi: 10.1111/bioe.12403. Epub 2017 Oct 11.
In this article, I ask whether a principle analogous to the principle of clinical equipoise should govern the design and conduct of RCTs evaluating the effectiveness of policy interventions. I answer this question affirmatively, and introduce and defend the principle of policy equipoise. According to this principle, all arms of a policy RCT must be, at minimum, in a state of equipoise with the best proven policy that is also morally and practically attainable and sustainable. For all arms of a policy RCT, policy experts must either (1) reasonably disagree about whether the trial arms are more effective than this policy, or (2) know that they are.
在本文中，我探讨了一条类似于临床 equipoise 原则的原则是否应指导评估政策干预效果的随机对照试验（RCT）的设计与实施。我对这个问题的回答是肯定的，并引入并捍卫了政策 equipoise 原则。根据这一原则，政策随机对照试验的所有组至少必须处于与已证实的最佳政策的 equipoise 状态，该最佳政策在道德、实践上也是可实现和可持续的。对于政策随机对照试验的所有组，政策专家必须要么（1）就是否试验组比该政策更有效存在合理分歧，要么（2）知道试验组更有效。
